مجله علوم پزشکی صدرا

شماره جاری

بر اساس شماره‌های نشریه

بر اساس نویسندگان

بر اساس موضوعات

نمایه نویسندگان

نمایه کلیدواژه ها

درباره نشریه

اهداف و چشم انداز

اعضای هیات تحریریه

اصول اخلاقی انتشار مقاله

بانک ها و نمایه نامه ها

پیوندهای مفید

پرسش‌های متداول

فرایند پذیرش مقالات

اخبار و اعلانات

کاربرد گیاهان دارویی در درمان بیماری انگلی لیشمانیوز: یک مطالعه مروری دامنه‌ای

نوع مقاله : مقاله مروری

نویسندگان

1 استادیار و دکترای تخصصی انگل شناسی، گروه زیست شناسی، واحد اردبیل، دانشگاه آزاد اسلامی، اردبیل، ایران

2 کارشناس میکروبیولوژی، گروه زیست شناسی، واحد اردبیل، دانشگاه آزاد اسلامی، اردبیل، ایران

چکیده

بیماری‌های انگلی ازجمله لیشمانیوز از شایع‌ترین عفونت‌ها در سراسر جهان هستند که خطرات جدی را برای سلامت انسان به وجود آورده‌اند. با توجه به عوارض جدی داروهای شیمیایی و ناکارآمدی آن‌ها در برخی موارد، امروزه برای درمان بیماری‌های انگلی، گیاهان دارویی مورد توجه قرار گرفته است. این مطالعه مروری دامنه‌ای به‌منظور بررسی کاربرد گیاهان دارویی در درمان لیشمانیوز در جهان انجام شد. به‌منظور گردآوری اطلاعات علمی و مقالات تحقیقی به پایگاه‌های علمی Google Scholar، Pubmed، Magiran و Web Of Science مراجعه شد. کلیدواژه‌های مورد استفاده عبارت از Leishmaniasis، medicinal plants و Protozoal infection بودند. در این مطالعه، مقالات تحقیقی مربوط به 16 سال گذشته (2022-2006) تهیه شد.  از بین 385 مقاله تهیه شده، 43 مقاله با اهداف اصلی تحقیق مرتبط بود و مورد استفاده قرار گرفت. بر اساس یافته‌های این مقالات مشخص گردید که 32 نوع گیاه برای درمان بیماری لیشمانیوزیس مورد ارزیابی قرار گرفته‌اند. بر اساس نتایج این مطالعه مروری، اثر درمانی 32 نوع گیاه دارویی مختلف برای درمان بیماری انگلی لیشمانیوز مورد تأیید قرار گرفته است. از بین این گیاهان 3 مورد دارای اثر درمانی قوی‌تر و عوارض جانبی کمتر بودند که عبارت‌اند از اکلیل کوهی، آلوئه اتالنسیس و ایپکا.

کلیدواژه‌ها

عنوان مقاله [English]

Application of Medicinal Plants in Treatment of Leishmaniasis: A Scoping Review Study

نویسندگان [English]

  • Mohammad Taghi Ahady 1
  • Fatemeh Fahimi 2
  • Maedeh Naghizadeh 2

1 Assistant Professor and PhD of Parasitology, Department of Biology, Ardabil Branch, Islamic Azad University, Ardabil, Iran

2 B.Sc. of Microbiology, Department of Biology, Ardabil Branch, Islamic Azad University, Ardabil, Iran

چکیده [English]

Parasitic diseases, including leishmaniasis, are the most prevalent infections worldwide that have serious risks for human health. Due to the serious side effects of chemical drugs and their inefficiency in some cases, medicinal plants have recently been considered for treating parasitic diseases. This scoping review study aimed to investigate and identify the medicinal plants introduced to treat leishmaniasis throughout the world. Scientific websites, including Google Scholar, PubMed, Magiran, Web of Science, and Elsevier were used to collect scientific information and research papers. The used keywords are Leishmaniasis, Medicinal Plants, and Protozoal Infection. The data were extracted and collected using research papers published over the past 16 years (2006-2022). Forty-three papers from the overall 385 collected articles were selected for the present study because of their complete relationship with the main aim of the research. The selected articles investigated 32 plant species for the treatment of leishmaniasis. The results of this systematic review study confirmed the therapeutic effect of 32 different kinds of medicinal plants. Furthermore, among these plants, three had stronger therapeutic effects and fewer side effects, including Rosmarinus Officinalis, Aloe otallensis, and Cephalis ipecacuana.

کلیدواژه‌ها [English]

  • Protozoan infection
  • Leishmaniasis
  • Medicinal Plants
  • Parasitic disease
  • Natural medicines
مراجع
  1. Cock IE, Selesho MI, Van Vuuven SF. A review of the traditional use of South African medicinal plants for the treatment of selected parasite infection affecting humans. J. Ethnopharmacol. 2018; 220: 250-264.
  2. Da Silva PR, de Oliveira JF, da Silva
    AL, Queiroz CM, Feitosa APS, Duarte DMFA, et al. Novel indol-3-yl-thiosemicarbazone derivatives: Obtaining, evaluation of in vitro leishmanicidal activity and ultrastructural studies. CHEM-BIOL INTERACT. 2020; 315: 108899.
  3. Shah SM, Ullah F, Ayaz M, Sadiq A, Hussain S, Ali Shah A-H, et al. Benzoic Acid Derivatives of Ifloga spicata (Forssk.) Sch.Bip. as Potential Anti-Leishmanial against Leishmania tropica. Processes. 2019; 7(4): 208.
  4. Ohashi M, Amoa-Bosompem M, Kwofie KD, Agyapong J, Adegle R, Sakyiamah MM, et al. In vitro antiprotozoan activity and mechanisms of action of selected Ghanaian medicinal plants against Trypanosoma, Leishmania, and Plasmodium parasites. PHYTOTHER RES. 2018; 32(8): 1617-1630.
  5. Burza S, Croft S L, Boelaert M. Leishmaniasis. The lancet. 2018; 392(10151): 951-970.
  6. Oliveira DM, Furtado FB, Gomes AAS, Belut BR, Nascimento EA, Morais SAL, et al. Chemical Constituents and Antileishmanial and Antibacterial Activities of Essential Oils from Scheelea phalerata. ACS Omega. 2020; 5: 1363−1370.
  7. Badirzadeh A, Heidari-Kharaji M, Fallah-Omrani V, Dabiri H, Araghi A, Salimi Chirani A.Antileishmanial activity of Urtica dioicaextract against zoonotic cutaneous leishmaniasis. PLoS Negl Trop Dis. 2020; 14(1).
  8. Almoradie AM, Angeles RJ, Beltran EV, Ugali M, Valles NS, Los Banos ZD, et al. Cryptosporicidal Activity of Plant Extracts against Cryptosporidium parvum and Cryptosporidium hominis. Asian. J. Pharmacogn. 2018; 2(3): 22-31.
  9. Willcox M, Gilbert B. Traditional medicinal plants for the treatment and prevention of human paracitic diseases. Books.google.com 2009.
  10. Sarker J, Ali MR, Khan MA, Rahman MM, Hossain ASMS, Alam AHMK. The Plant Aerva sanguinolenta: A Review on Traditional uses, Phytoconstituents and Pharmacological Activities. Pharmacog Rev. 2019; 13(26): 89-92.
  11. Shams Aldini S A, Rajabalian S, Mirzaei M, Brofei M. Efficacy of mimosa tenuiflora extract on growth of leishmania protozoa in vitro. Iran J. Dermatol. 2006; 9(2): 173-178. [Persian]
  12. Can H, Kayalar H, Bozkurt B, Can Ş, DÖŞKAYA M, TÖZ S. In vitro anti-leishmanial activity of Sarcopoterium spinosum against Leishmania tropica. ANKARA UNIV VET FAK. 2018; 65: 373-377.
  13. Al- Hajj MMA, Al-Shamahy HA, Alkhatib BY, Moharram BA. In vitro anti leishmanial activity against cutaneous leishmania parasites and preliminary phytochemical analysis of four Yemeni medicinal plants. Univers. J. Pharm. Res. 2018; 3(4): 48-54.
  14. Kowa TK, Tchokouaha LRY, Cieckiewicz E, Philips TJ, Dotse E, Wabo HK, et al. Antileishmanial and cytotoxic activities of a new limonoid and a new phenyl alkene from the stem bark of Trichilia gilgiana (Meliaceae). NAT PROD RES. 2019; 1–7.
  15. Azadbakht M, Azadbakht M. Five prevalent antiprotozoal herbal drugs. J. Mazandaran Univ. Med. Sci. 2008; 18 (67): 118-132. [Persian]
  16. Dalimi A, Delavari M, Salimi Kia I. Evaluation of the Effect of Achillea biebersteinii afan Essential Oil on Leishmania major Promastigote and Amastigote Growth under In Vitro Conditions. Modares J. Med. Sci. Pathol. 2016; 18(2): 41-51.
  17. Barati M, Sharifi I, Sharififar F. Antileishmanial activity of Artemisia aucheri, Ferula asafoetid and Gossypium hirsutum extracts on Leishmania major promastigotes in vitro. J. Army Univ. Med. Sci. IR. Iran. 2010; 8(3): 166-172. [Persian]
  18. Kheiri Manjili H, Jafari H, Ramazani A, Davoudi N. Anti-leishmanial and toxicity activities of some selected Iranian medicinal plants. Parasitol. Res. 2012; 111(5): 2115–2121.
  19. Bonyadian M, Hejazi H, Azizi H, Habibian S, Sayahi E. Antileishmania activity of Levandula officinalis essence against Leishmania major in in vitro media. J. Shahrekord Univ. Med. Sci. 2015; 17(3): 93-101.
  20. Barati M, Sharifi I, Sharififar F. In vitro Evaluation of Anti-Leishmanial Activities of Zataria Multiflora Boiss, Peganum Harmala and Myrtus Communis by Colorimetric Assay. J. Kerman Univ. Med. Sci. 2010; 17(1): 32. [Persian]
  21. Khademvatan Sh, Eskandari A, Nejad BS, Najafi Sh. In vitro Anti‑Leishmanial Activity of Satureja khuzestanica Jamzad and Oliveria decumbens Vent. Extracts on Leishmania major and Leishmania infantum Promastigotes. J Rep Pharm. 2019; 8(2): 149-154.
  22. Shokri A, Saeedi M, Fakhar M, Morteza Semnani K, Keighobadi M, Hosseini Teshnizi S, et al. Antileishmanial Activity of Lavandula angustifolia and Rosmarinus Officinalis Essential Oils and Nano-emulsions on Leishmania major (MRHO/IR/75/ER). Iran J Parasitol. 2017; 12(4): 622-631.
  23. Rezaei R, Tappeh KH, Seyyedi S, Mikaili P. The Anti-leishmanial Efficacy of Artemisia dracunculus Ethanolic Extract in Vitro and Its Effects on IFN- γ and IL-4 Response. Iran J Parasitol. 2017; 12(3): 398-407. [Persian]
  24. Nigusse ZT, Wondifraw WA, Abate SM. Screening of Aloe otallensis Exudate and Its Effect on Leishmania aethiopica. Pharm Anal Acta. 2016; 7(11): 515.
  25. Zare S, Hatam Gh, Firuzi O, Bagheri A, Chandran JN, Schneider B, et al. Antileishmanial and pharmacophore modeling of abietane-type diterpenoids extracted from the roots of salvia hydrangea. J Mol struct. 2021; 1228:129447.
  26. Ilaghi M, Sharifi I, Sharififar F, Sharifi F, Tavakoli oliaee R, babaei Z, et al. The potential role and apoptotic profile of three medicinal plant extracts on leishmania tropica by MTT assay, macrophage model and flow cytometry analysis. Parasite epidemiol control.2021;12: e00201.
  27. Elso OG, Calvin M, Hernandez N, Syarlata T, Bach H, Catalan CAN, et al. Antiprotozoal compounds form urolepis hecatantha(Asteraceae). J Evid Based complementary Altern Med. 2021; 2021: 7.
  28. Tabrez S, Rahman F, Ali R, Alouffi AS, Alshehri BM, Alshammari FA, et al. Assessment of the antileishmanial potential of Cassia fistula Leaf Extract. ACS Omega. 2021; 6(3): 2318-2327.
  29. BALIKÇI B, GUNGOR N, Kolayli F, Hokelek M. In vitro Effect of Pelargonium sidoides on promastigote forms of leishmania infantum and leishmania tropica. Kafkas Univ vet fak Derg. 2021; 27(1): 51-56.
  30. Alvavenga TA, Alves OJA, Pagotti MC, Cunha WR, Silva MLA, Sales JdF, et al. In vitro antileishmanial activity of anacardium othonianum and isolated compounds against leishmania amazonensis. Acta Brasiiensis. 2021: 5(1): 44-47.
  31. Alkhaibari AM, Alanazi AD. Chemical composition and Insectidal, Antiplasmodial and Anti Leishmanial activity of Copparis spinosa essential oil and its main constituents. eCAM. 2022:2022
  32. Khan BA, Faiz S, Khan MK, Menaa F, Olah NK, Almoshari Y, et al. fabrication and Evaluation Of W\o Emulsion Loaded with Linum usitatiss eefficeccy. Antibiotics. 2022;11(4): 432
  33. Hikal WM, Hussein AH, Ahl SA. Antileishmanial derivates of natural products from Ricinus communis. AUJES. 2022;3(1):41-57
  34. Padilha Ferreira FB, Pereira Cabral MR, SARRAGIOTTO MH, MARIANO FERNANDEZ CM, CRISTIANI GAZIM Z, PIAU JUNIOR R, et al. Screening of six medicinal plant species for antileishmanial activity. Acta Pharm. 2021; 71: 399–414.
  35. Machín L, Tamargo B, Piñón A, Atíes RC, Scull R, Setzer WN, et al. Bixa orellana L. (Bixaceae) and Dysphania ambrosioides (L.) Mosyakin & Clemants (Amaranthaceae) Essential Oils Formulated in Nanocochleates against Leishmania amazonensis. Molecules. 2019; 24(23): 4222.
  36. Shadmand E, Solhjo K, hashemi tayer A. Determination of the Effect of Autologous Platelet Gel on Cutaneous Leishmaniasis Wounds Healing. Sci J Iran Blood Transfus Organ. 2019; 16 (2): 116-123. [Persian]
  37. Parvizi P, AlaeeNovin E. Simultaneous Detection of of Three Leishmania Species in Kaleybar, a Focus of Visceral Leishmaniasis in Northwest of Iran. J Ardabil Univ Med Sci. 2011; 11 (2): 121-133.
  38. Ahuja A, Chatterjee T, Gunjan M, Gahlot G, Baranwal AK, Singh K, et al. LEISHMANIASIS: RAINBOW OF PRESENTATIONS UNVEILED ON BONE MARROW. Int J Sci Res. 2020; 9(1): 2277 – 8179.
  39. Solomon M, Sahar N, Pavlotzky F, Barzilai A, Jaffe CL, Nasereddin A, et al. Mucosal Leishmaniasis in Travelers with Leishmania braziliensis Complex Returning to Israel. Emerg Infect Dis. 2019; 25(4).
  40. Kawakami MYM, Zamora LO, Araujo RS, Fernandes GP, Ricotta TQN, Oliveira LGDe, et al. Efficacy of nanoemulsion with Pterodon emarginatus Vogel oleoresin for topical treatment of cutaneous leishmaniasis. Biomed. Pharmacother. 2021; 13: 111109.
  41. Al-Abodi HRJ. TREATMENT OF PARASITIC INFECTION USING MEDICINAL PLANTS – GIFT OF NATURE. Int. J. Pharma. Bio. Sci. 2019; 10(1): 38-43.
  42. Albakhit S, khademvatan Sh, Doudi M. The evaluation of Methanolic and aqueous extracts effect of Zizyphus spina-Christi against Leishmania major (MHOM/IR/75/ER) promastigotes using MTT assay. Iran. J. Med. Microbiol. 2016; 10(3): 54-60.
  43. Bahmani M, Abbasi N, Hosseini M, Rafieian-kopaei M. concise review: Medicinal plants are effective against leishmaniasis. Biomed Res Ther. 2017;4(11): 1733-1748.
مجله علوم پزشکی صدرا
دوره 10، شماره 3
تیر 1401
صفحه 297-310
فایل ها
هم رسانی
ارجاع به این مقاله
آمار