نوع مقاله: مقاله مروری

نویسندگان

1 دکترای آموزش پرستاری، استادیار و عضو هیئت علمی دانشگاه علوم پزشکی قزوین، قزوین، ایران

2 دانشجوی کارشناسی ارشد روان پرستاری دانشگاه علوم پزشکی قزوین، قزوین، ایران

چکیده

اختلالات روانپزشکی شیوع بالایی در بین مراجعان به مراکز مراقبت‌های اولیه و پزشکان عمومی دارند. هسته اصلی درمان در بیماران روانپزشکی دارو می‌باشد، این داروها در طولانی‌مدت می‌تواند عوارضی همچون کاهش یا فزایش قند و چربی را در پی داشته باشد. در این مطالعه به بررسی اثرات این داروها بر قند و چربی خون در ایران پرداخته شده است، لازم به ذکر می‌باشد که سطح قند خون و لیپید می‌تواند متأثر از جغرافیا، نژاد، قومیت و رنگ پوست باشد، کمااینکه مطالعات زیادی در این رابطه موجود می‌باشد و این روابط بیان‌شده به کرات به اثبات رسیده است. در این مطالعه مروری با استفاده از پایگاه‌های اطلاعاتی Mag Iran ،SID ، Iran Doc و Noormags    تا پایان سال 1397 و پایگاه‌های اطلاعاتی بین الملیPubMed, ISI ,Web of knowledge Up To Date,و Google Scholar  تا پایان سال 2019   جستجو انجام گردید و در نهایت تعداد 8 مطالعه از بین30 مطالعه، مورد بررسی نهایی قرار گرفتند.  نتایج نشان داد کل افراد مورد بررسی در این مطالعه 824 نفر در 8 مقاله مورد بررسی بود. 6 مطالعه کارآزمایی بالینی، 1 مطالعه توصیفی و 1 مطالعه مورد- شاهدی می‌باشد. به‌طور کلی در بررسی مطالعات حاضر، اکثر مطالعات تأثیر افزایشی آنتی‌سایکوتیک‌های مهار‌کننده توأم را بر قند خون  که از این دسته دارویی کلوزاپین و سپس ریسپریدون تاثیر بیشتری برایجاد این عارضه دارویی دارند و همچنین تاثیر داروهای آنتی سایکوتیک مهار کننده دوپامین بر چربی خون مشهود می‌باشد. در مقایسه کلومیپرامین و فلوکستین، کلومیپرامین موجب افزایش قند خون و چربی خون گردید، ولی فلوکستین این عوارض را نداشت.

کلیدواژه‌ها

عنوان مقاله [English]

The Effect of Psychiatric Drugs on Blood Glucose and Lipid in Patients

نویسندگان [English]

  • Reza Zeighami 1
  • Arghavan Raesolhagh 2

1 Ph.D. in nursing education, assistant professor and faculty member of Qazvin University of Medical Sciences, Qazvin, Iran

2 MSc Student of Psychiatric Nursing, Qazvin University of Medical Sciences, Qazvin, Iran

چکیده [English]

Psychiatric disorders are highly prevalent among clients referred to primary care and general practitioners. Given that the main core of treatment in these patients is medication, these psychiatric drugs can cause long-term complications such as a decrease or increase in blood glucose and lipid. In this review study, the effects of these drugs on blood glucose and lipid in Iran have been addressed. It should be noted that blood glucose and lipid levels can be affected by several factors including environmental factors, geography, race, ethnicity, and even skin color. Moreover, many relevant studies approved the relationships among these variables repeatedly. In this review study, international databases of Web of Knowledge, ISI, PubMed, Google Scholar, SID, and Noormags databases (as national ones) were searched up to the end of 2019. Finally, eight studies out of 30 were investigated. The Total number of subjects studied in this study was 824 in 8 articles, which included six clinical trials, one descriptive study, and one case-control study. In general, in the present review study, most studies indicate the increasing effect of serotonin-dopamine antagonist antipsychotics on blood glucose (so clozapine and then risperidone, from this drug class, have a greater effect on the development of this complication), as well as the effects of dopamine antagonist antipsychotics on lipid profile in patients. Comparing clomipramine and fluoxetine, clomipramine increased blood glucose and lipids, but fluoxetine did not have these complications.

کلیدواژه‌ها [English]

  • Blood glucose
  • Psychiatric Agents
  • Blood Lipids
  • Antipsychotic Agents
  • Antidepressive Agents

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