مجله علوم پزشکی صدرا

بررسی مکانیسم استرس شبکه آندوپلاسمی و مسیر پاسخ پروتئین های تا نخورده در سرطان

نوع مقاله : مقاله مروری

نویسندگان

پونه مکرم 1
ساناز دستغیب 2
مروارید سیری 3
صدیقه رضایی 3

1 دکترای بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران

2 دانشجوی دکترا بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران

3 دانشجوی فوق لیسانس بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران

چکیده
تداخل در عملکرد طبیعی شبکه آندوپلاسمی تحت شرایط استرس منجر به راه اندازی مسیر کاملاً حفاظت شده ای تحت نام پاسخ استرس سلولی  یا پاسخ پروتئینهای تا نخورده (UPR; Unfolded protein response) می گردد که هدف اولیه این مسیر جبران اختلالات ایجاد شده یا بازگرداندن شرایط نرمال سلولی است و درصورت طولانی و شدید بودن استرس شبکه آندوپلاسمی حتی قادر به راه اندازی مسیر مرگ سلولی (Apoptosis) نیز می باشد. مسیر پاسخ به استرس پروتئین های بد تا شده دارای سه بازوی اصلی است که هریک پس از فعال شدن منجر به اثرات متفاوتی بر تغییر بیان ژنهای ضروری درون سلول می شوند. در سالهای اخیر مولکولهای تنظیم کننده پاسخ استرس شبکه آندوپلاسمی بعنوان گزینه های  بسیار قوی و موثر برای اهداف دارویی و درمانی در بسیاری از بیماری ها از جمله : سرطان، آلزایمر، پارکینسون، دیابت، بیماری های قلبی و کبدی و آلرژی مورد توجه محققین قرار گرفته اند.

کلیدواژه‌ها

استرس شیکه اندوپلاسمی
پاسخ پروتئین های تا نخورده
مرگ سلولی
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مجله علوم پزشکی صدرا
دوره 6، شماره 4
20
پاییز 1397
صفحه 317-330

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