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Evaluation of Endoplasmic Reticulum Stress Mechanism and Unfold Protein Response Signaling in Cancer

Document Type : Review Article

Authors

1 PhD of clinical biochemistry, Department of biochemistry, Shiraz University of medical sciences, Shiraz, Iran

2 PhD candidate in clinical biochemistry, Department of biochemistry, Shiraz University of medical sciences, Shiraz, Iran

3 Master of clinical biochemistry, Department of biochemistry, Shiraz University of medical sciences, Shiraz, Iran

Abstract

Perturbation of endoplasmic reticulum (ER) homeostasis under a stressful situation leads to a stress condition termed “ER stress” which induces the activation of a finely regulated program defined as unfolded protein response (UPR), whose primary aim is to restore disorders or normal cell conditions. Under prolonged or sustained ER, stress conditions may result in activation-induced cell death. The UPR has three main arms; activation of each arm can lead to various effects on the expression of essential genes in cells.
In recent years, ER stress response regulator molecules have been considered by the researchers as a very strong and effective candidate for pharmaceutical and therapeutic purposes in many diseases, including cancer, Alzheimer's disease, Parkinson's disease, diabetes, heart and liver diseases, and allergies.

Keywords

References
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Sadra Medical Journal
Volume 6, Issue 4
October 2018
Pages 317-330
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