نوع مقاله : مقاله پژوهشی

نویسندگان

1 دکترای تخصصی بیوشیمی بالینی، مرکز تحقیقات ناباروری، دانشگاه علوم پزشکی شیراز، شیراز، ایران

2 دکترای تخصصی بیوشیمی بالینی، دانشیار، دانشکده پزشکی، گروه بیوشیمی بالینی، دانشگاه علوم پزشکی شیراز، شیراز، ایران

3 کارشناسی ارشد بیوشیمی بالینی، کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی کرمان، کرمان، ایران

4 کارشناسی ارشد بیوشیمی بالینی، دانشکده پزشکی، گروه بیوشیمی بالینی، دانشگاه علوم پزشکی کرمان،کرمان، ایران

5 دکترای تخصصی بیوشیمی بالینی، استادیار، دانشکده پزشکی، گروه بیوشیمی، دانشگاه علوم پزشکی گناباد، گناباد،

10.30476/smsj.2021.84031.1072

چکیده

مقدمه: ساتوریا خوزستانیکا یکی از گیاهان بومی ایران است که که در مناطقی مانند خوزستان و لرستان رشد می­کند. این مطالعه با هدف بررسی اثرات مصرف ساتوریا خوزستانیکا در بهبود سطوح پروفایل لیپیدی و بویژه کاهش کلسترل خون، آنزیم های کبدی و پراکسیداسیون لیپیدی در همسترهای نر تحت رژیم غذایی پرچرب انجام شد.
روش‌ها: به این منظور تعداد 26 همستر در گروه کنترل (Control)، گروه تغذیه شده با رژیم غذایی پرچرب (HFD) و گروه با رژیم غذایی پرچرب و تیمار شده با عصاره آبی ساتوریا خوزستانیکا (HFD+S) دسته بندی شدند. پس از گذشت 10 روز از شروع مطالعه، گروه های دوم و سوم به مدت 30 روز تحت رژیم غذایی پرچرب قرار گرفتند. در طی 10 روز انتهایی این دوره گروه HFD+S روزانه ساتوریا خوزستانیکا را به میزان mg/kg 100  از طریق گاواژ دریافت کردند.
یافته‌ها: براساس نتایج بدست آمده تجویز روزانه ساتوریا خوزستانیکا به مدت 10 روز باعث کاهش قابل توجه سطوح سرمی برخی از فاکتورهای لیپیدی از جمله کلسترول تام،LDL-C  و نیز سطوح مالون دی آلدهید و آنزیم های کبدی در بین همسترهای تحت رژیم غذایی پرچرب شد.
نتیجه گیری: این نتایج از اثرات بالقوه مصرف ساتوریا خوزستانیکا در پیشگیری و درمان بیماری های قلبی عروقی حمایت می­کند.

کلیدواژه‌ها

عنوان مقاله [English]

The Effects of Satureja Khuzestanica on Lipid Profile, Liver Enzymes, and Oxidative Stress Markers in Male Hamsters with High Fat Diet

نویسندگان [English]

  • Sina Vakili 1
  • Fatemeh Zal 2
  • Ghasem Ebrahimi 3 4
  • Mahboobe Akbari 4
  • Mohammad Amin Momeni-Moghaddam 5

1 Ph.D, Infertility Research Center, Shiraz University of Medical Sciences, Shiraz,

2 Associate Professor, Biochemistry Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

3 M.Sc. in Clinical Biochemistry, Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran

4 M.Sc. in Clinical Biochemistry, Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran

5 Assistant Professor, Department of Nutrition and Biochemistry, Gonabad University of Medical Sciences, Gonabad, Iran

چکیده [English]

Introduction: Satureja Khuzestanica (S. Khuzestanica) is one of the native plants of Iran that grows in areas such as Khuzestan and Lorestan. The current study was designed to evaluate the effects of S. Khuzestanica on lipid profile, especially on decreasing serum cholesterol, liver enzymes, and lipid peroxidation in male hamsters with high fat diet.
Methods: 26 male hamsters were randomly divided into control, high fat diet (HFD), and high fat diet treated with S. Khuzestanica (HFD+S) groups. After 10 days of beginning the study, the two latter groups were fed with high fat diet for 30 days. During the last 10 days, the HFD+S group was treated with 100mg/kg/day S. Khuzestanica through the gavage.
Results: Data showed that administration of S. Khuzestanica for 10 days resulted in a significant reduction of total cholesterol, LDL cholesterol, liver enzymes, and malondialdehyde in the HFD+S group.
Conclusion: These results support the potential effects of the use of Satureia Khuzestanica in the prevention and treatment of cardiovascular diseases.

کلیدواژه‌ها [English]

  • Satureja
  • Cardiovascular diseases
  • Liver
  • High fat diet
  • Oxidative stress
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