مجله علوم پزشکی صدرا

شماره جاری

بر اساس شماره‌های نشریه

بر اساس نویسندگان

بر اساس موضوعات

نمایه نویسندگان

نمایه کلیدواژه ها

درباره نشریه

اهداف و چشم انداز

اعضای هیات تحریریه

اصول اخلاقی انتشار مقاله

بانک ها و نمایه نامه ها

پیوندهای مفید

فرایند داوری مقالات

رهیافت های نوین درمان پیری و چروکیدگی پوست با پپتیدهای زیست فعال صناعی

نوع مقاله : مقاله مروری

نویسندگان

1 دانشجوی دکترای تخصصی نانوفناوری دارویی، کمیته تحقیقات دانشجویی دانشکده داروسازی، دانشگاه علوم پزشکی شیراز، شیراز، ایران

2 استادیار گروه نانوفناوری دارویی، دانشکده داروسازی، دانشگاه علوم پزشکی شیراز، شیراز، ایران

چکیده

در طول دو دهه گذشته، به دلیل تکامل تکنیک های طراحی و سنتز و در عین حال درک مکانیسم های مولکولی اثر بخشی پپتیدها در بهبود مشکلات پوستی، کاربرد آنها به عنوان عوامل دارو – آرایشی گسترش یافته است. مزایای متعددی برای پپتیدهای زیست فعال از قبیل دسترسی، عملکرد متنوع و انتخابی در فیزیولوژی پوست و فقدان اثرات جانبی ایمنی زا در تجویز موضعی مطرح شده که توجه ویژه متخصصین پوست به استفاده بالقوه از آنها را به عنوان عوامل ضد چین و چروک پوست جلب نموده است. این پپتیدها دارای نقش های مختلف بیولوژیکی نظیر تنظیم سیگنال های ماتریکس خارج سلولی و تحریک سنتز کلاژن می باشند. همچنین، به عنوان پپتیدهای حامل، آنتی اکسیدانت، مهارکننده میانجی گرهای عصبی یا آنزیمی عمل می کنند. اگرچه، موانع متعددی برای کاربرد گسترده آنها در محصولات موضعی ضد پیری وجود دارد: الف) شواهد بالینی برای اثربخشی درمانی هنوز محدود است، ب) نفوذ پوستی به دلیل هیدروفیل بودن، جرم مولی بالا و اتصال به سایر مواد محدود است، و ج) هزینه های زیاد. انتقال پپتید از پوست به طور موثر توسط جذب افزاها، اصلاح شیمیایی پپتید، میکروانکپسیولاسیون و ایجاد تخلخل های ریز در پوست افزایش می یابد. امروزه بیش از سی نوع پپتید به عنوان عامل ضد پیری پوست معرفی شده که بعضا در فراورده های مراقبت از پوست استفاده می شود. این مقاله خلاصه ای از پپتیدهای موضعی با اثربخشی اثبات شده در مطالعات درون تن ارائه می دهد؛ بعلاوه، چالش ها و رویکردهای انتقال پپتید از راه پوست بحث می شود.

کلیدواژه‌ها

مراجع
  1. Pickart L. The human tri-peptide GHK and tissue remodeling. Journal of Biomaterials Science, Polymer Edition. 2008;19(8):969-88.
  2. Fuller-Iglesias H, Smith J, Antonucci TC. Theories of aging from a life-course and life-span perspective. Annual Review of Gerontology and Geriatrics, Volume 29, 2009: Life-Course Perspectives on Late Life Health Inequalities. 2009:1.
  3. Tosato M, Zamboni V, Ferrini A, Cesari M. The aging process and potential interventions to extend life expectancy. Clinical interventions in aging. 2007;2(3):401.
  4. Podolskiy DI, Gladyshev VN. Intrinsic versus extrinsic cancer risk factors and aging. Trends in molecular medicine. 2016;22(10):833-4.
  5. Uhlig T, Kyprianou T, Martinelli FG, Oppici CA, Heiligers D, Hills D, et al. The emergence of peptides in the pharmaceutical business: From exploration to exploitation. EuPA Open Proteomics. 2014;4:58-69.
  6. Pai VV, Bhandari P, Shukla P. Topical peptides as cosmeceuticals. Indian Journal of Dermatology, Venereology, and Leprology. 2017;83(1):9.
  7. Reddy B, Jow T, Hantash BM. Bioactive oligopeptides in dermatology: Part I. Experimental dermatology. 2012;21(8):563-8.
  8. Zhang L, Falla TJ. Cosmeceuticals and peptides. Clinics in dermatology. 2009;27(5):485-94.
  9. Fields K, Falla T, Rodan K, Bush L. Bioactive peptides: signaling the future. Journal of cosmetic dermatology. 2009;8(1):8-13.
  10. Fisher E. Uber einige derivate des glykocolls. Ber Dtsch Chem Ges. 1901;34:2868-77.
  11. Wieland T, Bodanszky M. The world of peptides: a brief history of peptide chemistry: Springer Science & Business Media; 2012.
  12. Rahnamaeian M, Vilcinskas A. Short antimicrobial peptides as cosmetic ingredients to deter dermatological pathogens. Applied microbiology and biotechnology. 2015;99(21):8847-55.
  13. Kligman AM. Cosmetics: a dermatologist looks to the future: promises and problems. Dermatologic clinics. 2000;18(4):699-709.
  14. Katayama K, Seyer JM, Raghow R, Kang AH. Regulation of extracellular matrix production by chemically synthesized subfragments of type I collagen carboxy propeptide. Biochemistry. 1991;30(29):7097-104.
  15. Katayama K, Armendariz-Borunda J, Raghow R, Kang AH, Seyer JM. A pentapeptide from type I procollagen promotes extracellular matrix production. Journal of Biological Chemistry. 1993;268(14):9941-4.
  16. Choi YL, Park EJ, Kim E, Na DH, Shin Y-H. Dermal stability and in vitro skin permeation of collagen pentapeptides (KTTKS and palmitoyl-KTTKS). Biomolecules & therapeutics. 2014;22(4):321.
  17. Lau WM, White AW, Gallagher S, Donaldson M, McNaughton G, Heard CM. Scope and limitations of the co-drug approach to topical drug delivery. Current pharmaceutical design. 2008;14(8):794-802.
  18. Pouillot A, Dayan N, Polla AS, Polla LL, Polla BS. The stratum corneum: a double paradox. Journal of cosmetic dermatology. 2008;7(2):143-8.
  19. PENTAPEPTIDE P. Ultraviolet a photoprotection: Aging and cutaneous mast cells.
  20. Puig A, Antón JG, Mangues M. A new decorin‐like tetrapeptide for optimal organization of collagen fibres. International journal of cosmetic science. 2008;30(2):97-104.
  21. Mondon P, Hillion M, Peschard O, Andre N, Marchand T, Doridot E, et al. Evaluation of dermal extracellular matrix and epidermal–dermal junction modifications using matrix‐assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications. Journal of cosmetic dermatology. 2015;14(2):152-60.
  22. Dutta RC, Puri A, Anand N. Immunomodulatory potential of hydrophobic analogs of Rigin and their role in providing protection against Plasmodium berghei infection in mice. International immunopharmacology. 2001;1(5):843-55.
  23. Sorsa T, Tjäderhane L, Salo T. Matrix metalloproteinases (MMPs) in oral diseases. Oral diseases. 2004;10(6):311-8.
  24. Watson R, Ogden S, Cotterell L, Bowden J, Bastrilles J, Long S, et al. A cosmetic ‘anti‐ageing’product improves photoaged skin: a double‐blind, randomized controlled trial. British Journal of Dermatology. 2009;161(2):419-26.
  25. Lintner K, Peschard O. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International journal of cosmetic science. 2000;22(3):207-18.
  26. Schagen S. Topical peptide treatments with effective anti-aging results. Cosmetics. 2017;4(2):16.
  27. Thorsen M, Yde B, Pedersen U, Clauden K, Lawesson S-O. Studies on amino acids and peptides-V: Syntheses of endothionated melanostatin analogs. Tetrahedron. 1983;39(20):3429-35.
  28. Trookman NS, Rizer RL, Ford R, Ho E, Gotz V. Immediate and long-term clinical benefits of a topical treatment for facial lines and wrinkles. The Journal of clinical and aesthetic dermatology. 2009;2(3):38.
  29. Murphy-Ullrich JE, Poczatek M. Activation of latent TGF-β by thrombospondin-1: mechanisms and physiology. Cytokine & growth factor reviews. 2000;11(1-2):59-69.
  30. Gorouhi F, Maibach H. Role of topical peptides in preventing or treating aged skin. International journal of cosmetic science. 2009;31(5):327-45.
  31. Aldag C, Teixeira DN, Leventhal PS. Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature. Clinical, cosmetic and investigational dermatology. 2016;9:411.
  32. Kaczvinsky JR, Griffiths CE, Schnicker MS, Li J. Efficacy of anti‐aging products for periorbital wrinkles as measured by 3‐D imaging. Journal of cosmetic dermatology. 2009;8(3):228-33.
  33. Robinson L, Fitzgerald N, Doughty D, Dawes N, Berge C, Bissett D. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin 1. International journal of cosmetic science. 2005;27(3):155-60.
  34. Lintner K. Cosmetic or dermopharmaceutical use of peptides for healing, hydrating and improving skin appearance during natural or induced ageing (heliodermia, pollution). Google Patents; 2003.
  35. Guttman C. Studies demonstrate value of procollagen fragment Pal-KTTKS. Dermatology Times. 2002;23(9).
  36. Philippe Moussou LD, Vincent Bardey OF, Yanusz Wegrowski F-X. Counteracting aging phenomena by new pure tetrapeptides with targeted efficacy. J Appl Cosmetol. 2009;27:63-71.
  37. Pauly G, Contet‐Audonneau JL, Moussou P, Danoux L, Bardey V, Freis O, et al. Small proteoglycans in the skin: new targets in the fight against skin aging. International journal of cosmetic science. 2009;31(2):154-.
  38. Hussein WM, Choi PM, Zhang C, Su M, Sierecki E, Johnston W, et al. Evaluation of lipopeptides as toll-like receptor 2 ligands. Current drug delivery. 2017;14(7):935-43.
  39. Abdel-Malek ZA, Kadekaro AL, Kavanagh RJ, Todorovic A, Koikov LN, McNulty JC, et al. Melanoma prevention strategy based on using tetrapeptide α-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity. The FASEB journal. 2006;20(9):1561-3.
  40. Ubeid AA, Zhao L, Wang Y, Hantash BM. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. Journal of Investigative Dermatology. 2009;129(9):2242-9.
  41. Iozumi K, Hoganson GE, Pennella R, Everett MA, Fuller BB. Role of tyrosinase as the determinant of pigmentation in cultured human melanocytes. Journal of Investigative Dermatology. 1993;100(6):806-11.
  42. Davis EC, Callender VD. Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment options in skin of color. The Journal of clinical and aesthetic dermatology. 2010;3(7):20.
  43. Kassim AT, Hussain M, Goldberg DJ. Open-label evaluation of the skin-brightening efficacy of a skin-brightening system using decapeptide-12. Journal of Cosmetic and Laser Therapy. 2012;14(2):117-21.
  44. Farwick M, Maczkiewitz U, Lersch P, Summers B, Rawlings AV. Facial skin‐lightening benefits of the tetrapeptide Pro‐Lys‐Glu‐Lys on subjects with skin types V–VI living in South Africa. Journal of cosmetic dermatology. 2011;10(3):217-23.
  45. Marini A, Farwick M, Grether‐Beck S, Brenden H, Felsner I, Jaenicke T, et al. Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects. Experimental dermatology. 2012;21(2):140-6.
  46. Jungersted JM, Bomholt J, Bajraktari N, Hansen JS, Klærke DA, Pedersen PA, et al. In vivo studies of aquaporins 3 and 10 in human stratum corneum. Archives of dermatological research. 2013;305(8):699-704.
  47. Dumas M, Sadick NS, Noblesse E, Juan M, Lachmann-Weber N, Boury-Jamot M, et al. Hydrating skin by stimulating biosynthesis of aquaporins. Journal of drugs in dermatology: JDD. 2007;6(6 Suppl):s20-4.
  48. Sanz MT, Campos C, Milani M, Foyaca M, Lamy A, Kurdian K, et al. Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro‐collagen lipopeptide, creatine, and urea on skin aging signs. Journal of cosmetic dermatology. 2016;15(1):24-30.
  49. Herndon JJ, Jiang L, Kononov T, Fox T. An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin. Journal of drugs in dermatology: JDD. 2015;14(7):699-704.
  50. Gruchlik A, Chodurek E, Dzierzewicz Z. Effect of gly-his-lys and its copper complex on TGF-β1 secretion in normal human dermal fibroblasts. Acta Pol Pharm. 2014;71:954-8.
  51. Pickart L, Schagen S. New data of the Cosmeceutical and tripeptide GHK. SOFW J. 2015;9:141.
  52. Abdulghani AA, Sherr A, Shirin S, Solodkina G, Tapia EM, Wolf B, et al. Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin-A pilot clinical, histologic, and ultrastructural study. Disease Management and Clinical Outcomes. 1998;4(1):136-41.
  53. Leyden J, Stevens T, Finkey M, Barkovic S, editors. Skin care benefits of copper peptide containing facial cream. American Academy of Dermatology 60th Annual Meeting; 2002: American Academy of Dermatology.
  54. Hussain M, Goldberg DJ. Topical manganese peptide in the treatment of photodamaged skin. Journal of Cosmetic and Laser Therapy. 2007;9(4):232-6.
  55. Smith KC. Botulinum toxin type A: new information about an old medicine. Skin Therapy Lett. 2011;16(8):3-6.
  56. Brandt F, O'CONNELL C, Cazzaniga A, Waugh JM. Efficacy and safety evaluation of a novel botulinum toxin topical gel for the treatment of moderate to severe lateral canthal lines. Dermatologic Surgery. 2010;36:2111-8.
  57. Ruiz M, Clares B, Morales M, Cazalla S, Gallardo V. Preparation and stability of cosmetic formulations with an anti-aging peptide. Journal of cosmetic science. 2007;58(2):157-71.
  58. Blanes‐Mira C, Clemente J, Jodas G, Gil A, Fernández‐Ballester G, Ponsati B, et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity. International journal of cosmetic science. 2002;24(5):303-10.
  59. Wang Y, Wang M, Xiao S, Pan P, Li P, Huo J. The Anti-Wrinkle Efficacy of Argireline, a Synthetic Hexapeptide, in Chinese Subjects. American journal of clinical dermatology. 2013;14(2):147-53.
  60. Zhmak MN, Utkin YN, Andreeva TV, Kudryavtsev DS, Kryukova EV, Tsetlin VI, et al. Peptide inhibitors of nicotinic acetylcholine receptor. Google Patents; 2017.
  61. Chhipa NM, Chaudhari B. Toxin as a Medicine. Journal of Current Pharmaceutical Research. 2012;9(1):11-8.
  62. Dragomirescu A, Andoni M, Ionescu D, Andrei F. The Efficiency and Safety of Leuphasyl—A Botox-Like Peptide. Cosmetics. 2014;1(2):75-81.
  63. Nino M, Iovine B, Santoianni P. Carnosine and N-acetylcarnosine induce inhibition of UVB erythema in human skin. Journal of cosmetics, dermatological sciences and applications. 2011;1(04):177.
  64. Zhou B-r, Ma L-w, Liu J, Zhang J-a, Xu Y, Wu D, et al. Protective effects of soy oligopeptides in ultraviolet B-induced acute Photodamage of human skin. Oxidative medicine and cellular longevity. 2016;2016.
  65. Andre‐Frei V, Perrier E, Augustin C, Damour O, Bordat P, Schumann K, et al. A comparison of biological activities of a new soya biopeptide studied in an in vitro skin equivalent model and human volunteers. International journal of cosmetic science. 1999;21(5):299-311.
  66. Sim G-S, Lee D, Kim J, An S, Choe T, Kwon T, et al. Black rice (Oryza sativa L. var. japonica) hydrolyzed peptides induce expression of hyaluronan synthase 2 gene in HaCaT keratinocytes. Journal of microbiology and biotechnology. 2007;17(2):271.
  67. Ochiai A, Tanaka S, Tanaka T, Taniguchi M. Rice bran protein as a potent source of antimelanogenic peptides with tyrosinase inhibitory activity. Journal of natural products. 2016;79(10):2545-51.
  68. LOING E, SUERE T, LAMARQUE E. Trifluoroacetyl-tripeptide-2 to target senescence for anti-aging benefits. Cosmetics and toiletries. 2012;127(4).
  69. Barba C, Méndez S, Roddick‐Lanzilotta A, Kelly R, Parra J, Coderch L, et al. Wool peptide derivatives for hand care. International journal of cosmetic science. 2008;30(1):74-.
  70. Reddy BY, Jow T, Hantash BM. Bioactive oligopeptides in dermatology: Part II. Experimental dermatology. 2012;21(8):569-75.
  71. Marepally S, Boakye CH, Shah PP, Etukala JR, Vemuri A, Singh M. Design, synthesis of novel lipids as chemical permeation enhancers and development of nanoparticle system for transdermal drug delivery. PloS one. 2013;8(12):e82581.
  72. Abolmaali SS, Tamaddon AM, Farvadi FS, Daneshamuz S, Moghimi H. Pharmaceutical Nanoemulsions and Their Potential Topical and Transdermal Applications. Iranian Journal of Pharmaceutical Sciences. 2011;7(3):139-50.
  73. Kalluri H, Banga AK. Transdermal delivery of proteins. Aaps Pharmscitech. 2011;12(1):431-41.
  74. Zhang S, Qiu Y, Gao Y. Enhanced delivery of hydrophilic peptides in vitro by transdermal microneedle pretreatment. Acta Pharmaceutica Sinica B. 2014;4(1):100-4.
مجله علوم پزشکی صدرا
دوره 7، شماره 3
55
تیر 1398
صفحه 317-334
فایل ها
هم رسانی
ارجاع به این مقاله
آمار