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تأثیر 12 هفته فعالیت هوازی بر سطح سرمی کاردیوتروپین-1 در زنان مبتلا به فشارخون بالا

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری تخصصی رشته فیزیولوژی ورزشی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

2 استادیار گروه تربیت بدنی و علوم ورزشی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

3 دانشیار گروه تربیت بدنی و علوم ورزشی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

چکیده

مقدمه: کاردیوتروپین-1 یک سیتوکین مرتبط با اینترلوکین-6 است که عملکرد محافظتی و هیپرتروفی آن روی میوسیت‌های قلب شناخته شده است. هدف از انجام تحقیق حاضر، بررسی تأثیر 12 هفته تمرین هوازی روی سطح سرمی CT-1 در زنان مبتلا به فشارخون بالا بود.
روش‌ها: در این مطالعه 35 زن سالمند با دامنۀ سنی 50 تا 70 سال انتخاب و به‌صورت تصادفی به دو گروه (20 نفر آزمایش و 15 کنترل) تقسیم شدند. برنامه تمرینی شامل تمرین هوازی‌ای از نوع فزاینده بود که سه جلسه در هفته و به مدت 12 هفته اجرا گردید. قبل از شروع تمرینات و 24 ساعت پس از انجام آخرین جلسه ترکیب بدنی، (وزن 96/1±74 و شاخص توده بدن6/3±27)، نمونه خونی گرفته شد. ارزیابی یافته با استفاده از آزمون تحلیل کواریانس (ANCOVA) و آزمون تعقیبی توکی در سطح معنی‌داری (05/0P≤) انجام شد.
یافته‌ها: طبق نتایج به دست آمده مشخص گردید، تفاوت معناداری بین فشار خون سیستولی و دیاستولی وجود دارد، اما در سطوح کاردیوتروپین-1 تفاوت معناداری مشاهده نشد (0000/0P=).
نتیجه‌گیری: نتایج این پژوهش نشان داد فعالیت هوازی روی فشارخون بیماران تأثیر مثبت دارد و می تواند به عملکرد بهتر قلب کمک کند. همچنین پاسخ و ترشح کاردیوتروپین-1 به شدت و مدت فعالیت ورزشی بستگی دارد.
 

کلیدواژه‌ها

عنوان مقاله [English]

The Impact of 12-Week Aerobic Exercise on Serum Levels of Cardiotrophin-1 in Female Patients with Hypertension

نویسندگان [English]

  • Somayeh Abedzadeh 1
  • Farshad Ghazaliyan 2
  • Hosein Abed Natanzi 2
  • Hojatollah Nikbakht 3
  • Mandana Gholami 2

1 Ph.D.Student of Department of Sport Physiology, Scince and Research Branch, Isiamic Azad University, Tehran, Iran

2 Assistant Professor, Department of Physical Education and Sport Sciences, Scince and Research Branch, Isiamic Azad University, Tehran, Iran

3 Associate Professor, Department of Physical Education and Sport Sciences, Scince and Research Branch, Isiamic Azad University, Tehran, Iran

چکیده [English]

Introduction: Cardiotrophin-1 (CT-1) is an interleukin-6-related cytokine with known hypertrophic and protective actions upon cardiac myocytes. The present study aimed to investigate the impact of 1- week aerobic exercise on serum levels of cardiotrophin-1 in female patients with hypertension.
Methods: in this study, 35 old women aged 50 to 70 were randomly divided into two groups (15 controls and 15 controls). The exercise program included aerobic exercises conducted increasingly 3 times a week for 12 weeks. Before the exercise, and 24 hours after the last session, blood samples and the body composition were taken. Data were collected and analyzed using one-way ANCOVA and Tukey post hoc test at a significant level of P≤0/05.
Results: According to the results, twelve weeks of exercise did not significantly affect CT-1 level.
Conclusion: Overall, it seems that 12-week aerobic exercise has been beneficial in patients with hypertension and has been improving myocardial function; however, further studies are needed.

کلیدواژه‌ها [English]

  • Aerobic Exercise
  • Cardiotrophin-1
  • Hypertension
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مجله علوم پزشکی صدرا
دوره 10، شماره 3
تیر 1401
صفحه 203-214
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هم رسانی
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