نوع مقاله: مقاله مروری

نویسندگان

1 دانشجوی دکترای تخصصی نانوفناوری دارویی، کمیته تحقیقات دانشجویی دانشکده داروسازی، دانشگاه علوم پزشکی شیراز، شیراز، ایران

2 استادیار گروه نانوفناوری دارویی، دانشکده داروسازی، دانشگاه علوم پزشکی شیراز، شیراز، ایران

10.30476/smsj.2019.81724.1000

چکیده

در طول دو دهه گذشته، به دلیل تکامل تکنیک های طراحی و سنتز و در عین حال درک مکانیسم های مولکولی اثر بخشی پپتیدها در بهبود مشکلات پوستی، کاربرد آنها به عنوان عوامل دارو – آرایشی گسترش یافته است. مزایای متعددی برای پپتیدهای زیست فعال از قبیل دسترسی، عملکرد متنوع و انتخابی در فیزیولوژی پوست و فقدان اثرات جانبی ایمنی زا در تجویز موضعی مطرح شده که توجه ویژه متخصصین پوست به استفاده بالقوه از آنها را به عنوان عوامل ضد چین و چروک پوست جلب نموده است. این پپتیدها دارای نقش های مختلف بیولوژیکی نظیر تنظیم سیگنال های ماتریکس خارج سلولی و تحریک سنتز کلاژن می باشند. همچنین، به عنوان پپتیدهای حامل، آنتی اکسیدانت، مهارکننده میانجی گرهای عصبی یا آنزیمی عمل می کنند. اگرچه، موانع متعددی برای کاربرد گسترده آنها در محصولات موضعی ضد پیری وجود دارد: الف) شواهد بالینی برای اثربخشی درمانی هنوز محدود است، ب) نفوذ پوستی به دلیل هیدروفیل بودن، جرم مولی بالا و اتصال به سایر مواد محدود است، و ج) هزینه های زیاد. انتقال پپتید از پوست به طور موثر توسط جذب افزاها، اصلاح شیمیایی پپتید، میکروانکپسیولاسیون و ایجاد تخلخل های ریز در پوست افزایش می یابد. امروزه بیش از سی نوع پپتید به عنوان عامل ضد پیری پوست معرفی شده که بعضا در فراورده های مراقبت از پوست استفاده می شود. این مقاله خلاصه ای از پپتیدهای موضعی با اثربخشی اثبات شده در مطالعات درون تن ارائه می دهد؛ بعلاوه، چالش ها و رویکردهای انتقال پپتید از راه پوست بحث می شود.

کلیدواژه‌ها

عنوان مقاله [English]

Recent Approaches in the Treatment of Skin Ageing by Synthetic Bioactive Peptides

نویسندگان [English]

  • Haniye Najafi 1
  • Mahboobe Jafari 1
  • Samirasadat Abolmaali 2

1 Ph.D. Candidate in Pharmaceutical Nanotechnology, Student Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran

2 Assistant Professor, Department of Pharmaceutical Nanotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

چکیده [English]

Over the last two decades, due to the advances in the techniques used in the design and synthesis of peptides as well as the understanding of the underlying molecular mechanisms involved in their therapeutic action on skin disorders, novel applications have been emerged for peptides as cosmeceuticals. There are several advantages in the use of   bioactive and biomimetic peptides such as availability, diverse and selective mode of action in skin physiology, and lack of immunogenic reactions that have attracted skin specialists’ attention for their potential use as anti-wrinkle agents. These peptides are known to have various biological roles against skin ageing, most prominently as extracellular matrix signal modulators and collagen synthesis stimulants. In addition, they may act as carrier peptides, antioxidants, neurotransmitter or enzyme inhibitors. However, they are facing a few obstacles for widespread applications in topical anti-ageing skin products: a) clinical evidence for the therapeutic efficacy is still limited; b) skin penetration may be weak due to their hydrophilicity, high molar mass, and binding to other ingredients; and c) high cost. Peptide transport through skin can be effectively boosted by penetration enhancers, lipophilic modifications, peptide microencapsulation, and skin microporation. There are currently more than 30 therapeutic peptides that have been occasionally introduced into the market of skin care products. This review summarizes different classes of topical peptides with proven effectiveness against skin ageing in-vivo. Moreover, the challenges of and approaches to peptide transport through skin OR (the delivery challenges and approaches) are discussed.

کلیدواژه‌ها [English]

  • Anti-Wrinkle
  • Bioactive
  • Cosmeceuticals
  • Peptide
  • Skin Ageing

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