Sadra Medical Journal

Investigating the Cases of Pupillary Paraffinoma Following Surgery on the Paranasal Sinus Surgeries: Case Series

Document Type : Case Report

Authors

Behzad Khademi 1
Naser Owji 2
Elham Sadeghi 3
Zahra Zia 1, 4
Fatemeh Ebrahimi 3
Ali Azimi 1
Mohammad Hassan Jalalpour 1
Reza Jahangir 5

1 Assistant Professor, Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Professor, Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3 Post-doctoral, Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

4 Department of Ophthalmology, Jahrom University of Medical Sciences, Jahrom, Iran

5 Assistant Professor, Otolaryngology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

https://doi.org/10.30476/smsj.2024.103168.1550
Abstract
Introduction: In medicine, paraffinoma is a rare and intriguing condition. This condition is characterized by an orbital lipogranulomatosis reaction caused by the penetration of mineral oils (especially paraffin) into the tissues surrounding the eye.
Patients’ Presentation: This case series reported three cases of orbital paraffinoma. All cases were occurred following endoscopic paranasal sinus surgery. Consequently, a literature review was conducted on orbital and peri-ocular paraffinoma. The disease-related data were classified into disease definition, differential diagnosis, clinical manifestation, radiological manifestation, histopathological diagnosis, and treatment methods, which were comprehensively reviewed.
Conclusion: Paraffinoma is a rare and time-delayed diagnosis following various peri-orbital surgeries, which might challenge the physician to make an accurate diagnosis at first. When patients with a history of sinus and nose surgery have masses around their orbit and eyelids, ophthalmologists should take this diagnosis into account in addition to other differential diagnoses. Therefore, otolaryngologists and ophthalmologists should prioritize prompt prevention and timely management.

Keywords

Paraffinoma
Eye diseases
Foreign-body reaction
Mineral oil
Paraffin
Paranasal sinuses
  1. Coulier B, Desgain O, Gielen I. Sinonasal myospherulosis and paraffin retention cysts suggested by CT: report of a case. Head Neck Pathol. 2012;6(2):270-4.
  2. Kim HK, Kim BJ, Kim MN, Kim SY, Kim SE, Mun SK, et al. Facial paraffinoma treated with a bipolar radiofrequency device. Int J Dermatol. 2015;54(1):89-91.
  3. Park KG, Dhong ES, Namgoong S, Han JK, Han SK, Kim WK. Atypical Facial Filler Granuloma: Comparative Histologic Analysis with Paraffinoma. Arch Craniofac Surg. 2016;17(3):169-72.
  4. Uchida Y, Yoshii N, Kubo H, Kanzaki T, Kanekura T. Facial paraffinoma after cosmetic paraffin injection. The Journal of Dermatology. 2007;34(11):798-800.
  5. Govaerts J, Vercruysse JP, Samoy K, De Groot V, Jorissen M, Claes J. Myospherulosis as a complication of functional endoscopic sinus surgery: a double case report. B-ENT. 2013;9(4):339-42.
  6. Rosner M, Kurtz S, Shelah M, Rosen N. Orbital lipogranuloma after sinus surgery. European journal of ophthalmology. 2000;10(2):183-6.
  7. Witschel H, Geiger K. Paraffin induced sclerosing lipogranuloma of eyelids and anterior orbit following endonasal sinus surgery. Br J Ophthalmol. 1994;78(1):61-5.
  8. Hasegawa T, Yukawa K, Suzuki M, Komiya T, Watanabe K. A case of eyelid paraffinoma that developed after endoscopic sinus surgery. Auris Nasus Larynx. 2011;38(4):538-42.
  9. Keefe MA, Bloom DC, Keefe KS, Killian PJ. Orbital paraffinoma as a complication of endoscopic sinus surgery. Otolaryngol Head Neck Surg. 2002;127(6):575-7.
  10. Friedrich RE, Zustin J. Paraffinoma of lips and oral mucosa: Case report and brief review of the literature. GMS Interdiscip Plast Reconstr Surg DGPW. 2014;3:Doc05.
  11. Goldwyn RM. The paraffin story. Plastic and reconstructive surgery. 1980;65(4):517-24.
  12. Martinez-Villarreal AA, Asz-Sigall D, Gutierrez-Mendoza D, Serena TE, Lozano-Platonoff A, Sanchez-Cruz LY, et al. A case series and a review of the literature on foreign modelling agent reaction: an emerging problem. Int Wound J. 2017;14(3):546-54.
  13. Merkur AB, Jardeleza MSR, Iliff NT, Iliff WJ, Miller NR, Green WR. Periocular petrolatum. Ophthalmic Plastic & Reconstructive Surgery. 2005;21(1):23-31..
  14. Bachor E, Dost P, Unger A, Ruwe M. [Paraffinoma--a rare complication following endonasal surgery]. Laryngorhinootologie. 1999;78(6):307-12.
  15. Feldmann R, Harms M, Chavaz P, Salomon D, Saurat JH. Orbital and palpebral paraffinoma. J Am Acad Dermatol. 1992;26(5 Pt 2):833-5.
  16. Montgomery PQ, Khan JI, Feakins R, Nield DV. Paraffinoma revisited: a post-operative condition following rhinoplasty nasal packing. J Laryngol Otol. 1996;110(8):785-6.
  17. Hintschich C, Beyer-Machule C, Stefani F. Paraffinoma of the periorbit—a challenge for the oculoplastic surgeon. Ophthalmic Plastic & Reconstructive Surgery. 1995;11(1):39-43.
  18. Daley T, Damm DD, Haden JA, Kolodychak MT. Oral lesions associated with injected hydroxyapatite cosmetic filler. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(1):107-11.
  19. Borrie J, Gwynne JF. Paraffinoma of lung: lipoid pneumonia. Report of two cases. Thorax. 1973;28(2):214-21.
  20. Grassetti L, Lazzeri D, Torresetti M, Bottoni M, Scalise A, Di Benedetto G. Paraffinoma of the knee 60 years after primary injection. Arch Plast Surg. 2013;40(6):789-90.
  21. De Gado F, Mazzocchi M, Chiummariello S, Gagliardi DN, Alfano C. Johnson’s baby oil, a new type of filler ? Acta Chir Plast. 2006;48(4):123-6.
  22. Seo JW, Sa HS. Periorbital Lipogranuloma Following Facial Autologous Fat Injections: Non-surgical Treatment. Aesthetic Plast Surg. 2015;39(6):946-52.
  23. van der Waal I. Paraffinoma of the face: a diagnostic and therapeutic problem. Oral Surg Oral Med Oral Pathol. 1974;38(5):675-80.
  24. Juel J, Grejsen DV, Pareek M. Long-term adverse effects of intramuscular oil injection. Case Reports. 2017;2017:bcr-2017-220698.
  25. Cormio L, Di Fino G, Scavone C, Selvaggio O, Massenio P, Sanguedolce F, et al. Magnetic resonance imaging of penile paraffinoma: case report. BMC Med Imaging. 2014;14:39.
  26. Francis J, Choo APC, Khin-Lin GW. Ultrasound and MRI features of penile augmentation by †œJamaica Oil†injection. A case series. Medical Ultrasonography. 2014;16(4):372-6.
  27. Alcalde-Alonso M, Velasco-Albendea FJ, Soto-Diaz A, Gomez-Avivar P, Torres-Gomez FJ. Paraffinoma of the penis and scrotum (sclerosing granuloma of the male genitalia). Indian J Dermatol Venereol Leprol. 2017;83(1):75-7.
  28. Gu DH, Yoon DY, Chang SK, Lim KJ, Cha JH, Seo YL, et al. CT features of foreign body granulomas after cosmetic paraffin injection into the cervicofacial area. Diagn Interv Radiol. 2010;16(2):125-8.
  29. Torre K, Murphy M, Ricketts J. Facial lipogranulomas due to self-injection of vitamin A oil. International Journal of Women’s Dermatology. 2019;5(2):126-8.
  30. Eun YS, Cho SH, Lee JD, Kim HS. Periorbital lipogranuloma related to filler migration: a rare complication of facial fillers. J Cosmet Laser Ther. 2014;16(3):149-50.
  31. Yeo IK, Kim BJ, Kim MN, Mun SK, Koh HJ, Kim H, et al. Treatment of facial paraffinoma with a bipolar radiofrequency device. J Dermatol. 2013;40(9):762-3.
  32. JP ME, JM JL. Penile paraffinoma after subcutaneous injection of paraffin. Treatment with a two step cutaneous plasty of the penile shaft with scrotal skin. Archivos Espanoles de Urologia. 2012;65(5):575-8.
  33. Vladislav D, Pencho G, Stoykov B, Kolev N. Unmeshed split-thickness SKIN grafts for penile plastic in patients with paraffinoma. Urol Case Rep. 2020;32:101249.
Sadra Medical Journal
Volume 12, Issue 4
Autumn 2024
Pages 650-658

Home

Guide for Authors

Submit Manuscript

Guide for Reviewers

Contact Us