Sadra Medical Journal

The Synergistic Intervention of Submaximal Aerobic Exercise and Flaxseed Oil Supplementation on Gene Expression of Adiponectin and Omentin-1 Hormones in Visceral Adipose Tissue of Obese Male Wistar Rats

Document Type : Original Article

Authors

Mahmood Amani 1
Farzad Nazem 2
Hossein Saki 3

1 Master of Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, Bu-Ali Sina University, Hamedan, Iran

2 Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Sport Sciences, Bu-Ali Sina University, Hamedan, Iran

3 PhD in sport physiology, Department of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamedan, Iran

https://doi.org/10.30476/smsj.2024.99571.1430
Abstract
Introduction: Omentin-1 is a newly discovered adipokine often secreted from visceral adipose tissue and is inversely related to obesity. Additionally, the adipocyte-specific protein adiponectin plays a significant role in the metabolic effects of obesity. This study aimed to investigate the interventions of submaximal aerobic exercise and flaxseed oil supplementation on the expression of adiponectin and omentin-1 hormone genes in obese rats.
Methods: Thirty laboratory rats were divided into five equal groups: a) a control group (with normal food consumption), and four groups with high-fat food consumption including b) linseed oil supplement, c) a submaximal exercise program, d) a combination of exercise intervention and flax oil supplement, and e) sham group (high-fat diet). An aerobic training program of running with an intensity equal to 55-70% vo2max was implemented five days a week for eight weeks. The intervention of linseed oil, one gram per kilogram of the weight of obese rats, was also administered to the rats five days a week for eight weeks.
Results: The exercise program intervention increased the gene expression of adiponectin and omentin-1 hormones in visceral white adipose tissue of obese rats (P<0.05). Flaxseed oil supplementation had a significant effect on the expression of the adiponectin hormone gene (P<0.05), but there was no change in the expression of the omentin-1 gene (P>0.05). However, the simultaneous intervention of independent variables significantly affected the gene expression of adiponectin and omentin-1 hormones in rats (P<0.05).
Conclusion: The simultaneous intervention of submaximal aerobic exercise and linseed oil supplementation has a more pronounced effect than either of the two independent variables on increasing the expression of adiponectin and omentin-1 genes, and it likely leads to the control of body weight in obese rats.

Keywords

Obesity
Rats
Exercise
Linseed oil
Omentin-1
Adiponectin
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Sadra Medical Journal
Volume 12, Issue 3
Summer 2024
Pages 330-340

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