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Comparison of the Infection of Toxoplasma Gondii and Aggression in Autism and Normal Children

Document Type : Original Article

Authors

1 Associate Professor of Clinical Psychology, Department of Clinical Psychology, Faculty of Educational Sciences and Psychology, Shahid Chamran University of Ahvaz, Ahvaz, Iran

2 MSc Student of Clinical Psychology, Department of Clinical Psychology, Faculty of Educational Sciences and Psychology, Shahid Chamran University of Ahvaz, Ahvaz, Iran

3 Professor of Pathobiology, Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Abstract

Introduction: This study aimed to compare the infection of ToxoplasmaGondii and aggression in autism and normal children.
Methods: The research method was causal-comparative while it is considered as an applied research. The participants included (N=100) 50 autistic children and 50 normal children ranging from 3 to 12 years old; they were homogenous in terms of age, socio-economic status, the severity of the disorder, lack of physical and mental illness, and other criteria considered in this research. Then the researchers divided them randomly into two groups as experimental and control. Of each group, 5ml blood samples were collected to assess the prevalence of toxoplasma. To investigate the hypothesis, non-parametric Kai-Dwo test, Mann-Whitney U test, and Kruskal-Wallis test were used to analyze the data. The instruments were preschool aggression scale (Vahedi et al, 1387), and Elisa reder to essay the blood sample test.
Results: The results showed that children with autism had more pollution to Toxoplasma Gondii in comparison with the normal group.
Conclusion: Children with autism who had parasites were more aggressive than non-infected children who had autism (P=0/05).

Keywords

References
  1. Dalimi A, Abdoli A. Latent toxoplasmosis and human. Iran J Parasitol. 2012; 7: 1-17. (Persian).
  2. Pomares C, Montoya JG. Laboratory diagnosis of congenital toxoplasmosis. Journal of clinical microbiology. 2016;54(10):2448-54.
  3. Paquet C, Yudin MH. Toxoplasmosis in pregnancy: prevention, screening, and treatment. Obstet Gynaecol Can.2013, 35:78-9.
  4. Franchini M, Glase B, Genta E, Wood H, Eliez S, Schaer M. The effect of emotional intensity on responses to joint attention in preschoolers with an autism spectrum disorder. Research in Autism Spectrum Disorders 2017; 35: 13-24.
  5. Kieffer F, Wallon M. Congenital toxoplasmosis. Handb Clin Neurol, 2013, 112: 1099-1011.
  6. Han Y M Y & Chan A S. Disordered cortical connectivity underlies the executive function deficits in children with autism spectrum disorders. Research in Developmental Disabilities, 2017, 61: 19-31.
  7. Teague SJ, Gray KM, Tonge BJ. & Newman LK. Attachment in children with autism spectrum disorder: A systematic review. Research in Autism Spectrum Disorders, 2017, 35:35-50.  
  8. Flegr J, Hrdy I. Influence of chronic toxoplasmosis on some human personality factors. Folia Parasitol, 1994; 41(2):122-6.
  9. Flegr J, Zitkova S, Kodyn P, Frynta D. Induction of changes in human behavior by the parasitic protozoan Toxoplasma gondii. Parasitology, 1996; 113(1):49-54.
  10. Xie Y, Zhang X, Liu F, Qin W, Fu J, Xue K, Yu C. Brain mRNA Expression Associated with Cortical Volume Alterations in Autism Spectrum Disorder. Cell Reports. 2020;32(11):108137.
  11. American Psychiatric Association. Diagnostic and statistical manual of mental disorders.2017.
  12.  Ben-Itzchak E, Koller J, Zachor DA. Characterization and Prediction of Anxiety in Adolescents with Autism Spectrum Disorder: A Longitudinal Study. Journal of abnormal child psychology. 2020;48(9):1239-49.
  13. Yang CJ, Tan HP. & Du, YJ. The developmental disruptions of serotonin signaling May involved in autism during early brain development. Neuroscience, 2014, 267C:1–10.
  14. Rostami A, Riahi SM, Contopoulos-Ioannidis DG, Gamble HR, Fakhri Y, Shiadeh MN, Foroutan M, Behniafar H, Taghipour A, Maldonado YA, Mokdad AH. Acute Toxoplasma
    infection in pregnant women worldwide: A systematic review and meta-analysis. PLoS neglected tropical diseases. 2019;13(10): e0007807. (Persian (.
  15. Bransfield RC. Preventable cases of autism: Relationship between chronic in factious diseuses and neurological outcome. Pediatr Health, 2009; 3 (2): 125- 40.
  16. Abbasian L, Talebi Meymand F, Shirbazou SH. Role of Toxoplasma gondii infection in serum level of Testosterone. Kowsar Medical Journal, 2011, 16(2): 123-127. )Persian(.
  17. Khan AH, Noordin R. Serological and molecular rapid diagnostic tests for Toxoplasma infection in humans and animals. European Journal of Clinical Microbiology & Infectious Diseases. 2020;39(1):19-30.
  18. Young SN. How to increase serotonin in the human brain without drugs? J Psychiatry Neuroscience.2007, 32(6): 394–399.
  19. Williams E, Stewart-Knox B, Helander A, et al. Associations between whole-blood serotonin and subjective mood in healthy male volunteers. Biol Psychol, 2006; 71:171-4.
  20. Afsharpaiman SH, Skandari A, Zareian Jahromi M, Radfar SH, Shirbazoo SH, Amirsalari S, Torkaman M. An assessment of Toxoplasmosis antibodies seropositivity in children suffering Autism. Tehran University Medical Journal, 2014; 72(2): 106-112. )Persian(.
  21. Vahedi SH, Fathiazar A, Hosseini-Nasab D, Mokhadam M.  Reliability and validity of preschool aggression scale and study the aggression in preschool children in Aromieh city. The Journal of principal mental health, 2007, 10, 37: 15-24. (Persian).
  22.  Rajabpour M, Makvand Hosseini S H, Rafienia P. The effect of patent-child group therapy on aggression of preschool children. The Journal of clinical Psychology, 2013, 4 (1): 13-14. (Persian).
  23. Bransfield RC. Preventable cases of  autism: Relationship between chronic in factious diseuses and neurological outcome. Pediatr Health, 2009; 3 (2): 125- 40.
  24. Gillberg C, Colman M, Tnfectious in: Gillberg C, Coleman M. The Biology of the Autistic Syndromes. 2th ed. London, UK: Mac Keith Press, 1992: 218- 25.
  25. Deykin EY, Maxmahon B. Viral exposure and autism. Am J Epidemiol. 109(6): 628-38. Wing L. Autistic spectrum disorders. BMJ 1996; 312 (7027):327–328.
  26. Aly BB, Fasihi-Harandi M, Nazari A, Salari Z. The Comparison of Anti-Toxoplasma antibodies in pregnancies ended in abortion and Natural
    pregnancies. Kerman University of Medical Sciences, 2010, 6:3-6. (Persian).
  27. Patterson P H. Animal models of the maternal infection risk factor for schizophrenia. In: Brown AS, Patterson PH, editor. The Origins of Schizophrenia. New York: Columbia University Press, 2016, 255–281.
  28. Prandota J. Autism spectrum disorders may be due to cerebral toxoplasmosis associated with chronic neuroinflammation causing persistent hypercytokinemia that resulted in an increased lipid peroxidation, oxidative stress, and depressed metabolism of endogenous and exogenous substances. J Prandota Res Autism Spectrum Dis; 5(1):14-59.
  29. Dubey P. Toxoplasma gondii oocyst Survival under defined Temperatures.1998, 1 Parasitol; 862- 5
  30. Saadatnia G. Toxoplasmosis Infection in Pregnant Women. Sarem Journal of Reproductive Medicine. 2017;1(3):127-31.  (Persian).
  31. Yolken RH. Antibodies to Toxoplasma gondii in individuals with first-episode schizophrenia. Clin Infect Dis.2009, 32:842–844.
  32. Yang CJ, Tan HP, Du YJ. The developmental disruptions of serotonin signaling may involved in Autism during early brain development. Neuroscience. 2014;267:1-10.
  33. Hashemi H, Saraei M. Seroprevalence of Toxoplasma gondaii in unmarried Woman in Qazvin, lslamic Republic of Iran. Eust Mediterr Health, 2010, 1; 16 (1): 24-8. (Persian).
  34. Charavi M. Seroepidemiobgical Surrey if Toxoplasmosis in pregnant. Woman in Tehran. Hakim Reasearch, 2002; 5 (2): 113. (Persian).
  35. Kanner L. Autistic Disturbances of affective contact. Nervous child, 1994, 21, 217- 250.
  36. Trevarthen C, Delafield-Butt J. The early development of autism spectrum disorder and its care. InAutism. 2020: 33-42). Academic Press.
  37. Tate B G, Baroff G S. Aversive control of self – injurious behavior in a psychotic boy. Behavior Research and Therapy, 1996, 4, 281-287.
  38. AL-Maamuri SD, AL-Shanawi FA, Melconian AK. Seroprevalence of Toxoplasma gondiiin Schizophrenic Patients in Iraq using ELISA test. Iraqi Journal of Science, 2014, 55, No.3B: 1243-1248.
  39. Al-Hassnawi A. Toxoplasma gondii may be an advisor for aggressiveness: Seroprevalence of toxoplasmosis in murderer women in Iraq, American Journal of Biology and Life Sciences, 2014; 2(6): 187-190.
  40. Yolken R H, Dickerson FB, & Torrey E F. Toxoplasma and Schizophrenia.
    Parasite lmmunology. 2009,31: 706- 15
  41. Flegr J. Effects of Toxoplasma on human behavior. Schizophr Bull. 2007, 33 (3): 757- 60.
  42. Amininger G P. Antibodies to infections agents in individuals at ultra – high risk for Psychosis. Biol Psychiatry.2009, 61: 1215- 1217.
  43. Flegr J, Lindova J, pivonkova V, Havlicek A. Lutent Toxoplasmosis and solivary testosterone concen tration: Important confounding foctors in second to fourth digit ration studies. An m J Phys Anthro pol.2008, 137 (4): 479- 82.
Sadra Medical Journal
Volume 8, Issue 3
July 2020
Pages 249-262
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