Document Type : Original Article
Authors
Abstract
Background: Considering the relationship between oral and systemic diseases and definite role of oral infections in pathological processes elsewhere in the body, this study aimed to investigate the effect of non-surgical periodontal therapy on serum levels of anti-cardiolipin antibodies (aCLA) that potentially plays a role in the pathogenesis of cardiovascular diseases in the patients with periodontitis.
Methods: The present study was conducted on 20 volunteers (11 females and 9 males) with the mean age of 40.55 years. Generalized chronic periodontitis was diagnosed thorough clinical periodontal examination at baseline visit. This examination included measurement of probing Pocket Depth (PD) and clinical Attachment Loss (AL). The Plaque Index (PI) and Gingival Index (GI) were recorded, as well. After baseline examination, all the subjects received full mouth non–surgical periodontal treatment. The subjects returned for the final visit 6 weeks after the last session of the scaling for reevaluation of the periodontal parameters. At baseline and final visits, two milliliters of venous blood was collected from each patient and a commercially available enzyme-linked immunosorbent assay (ELISA) was used for analyzing aCLA (IgM and IgG). Then, the data were entered into the SPSS statistical software and analyzed using paired sample t test.
Results: A significant difference was found regarding the mean levels of both forms of aCLA before and after the treatment (P=0.003 for IgM and P=0.001 for IgG). In addition, the study results showed significant reductions in the periodontal parameters after non-surgical periodontal therapy (P<0.001).
Conclusions: The results of this study suggested that successful periodontal therapy could improve the serum level of one of the inflammatory biomarkers involved in the cardiovascular problems (aCLA).
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