Document Type : Original Article
Authors
1 Department of Exercise Physiology, Gilan-E-Gharb Branch, Islamic Azad University, Gilan-E-Gharb, Iran
2 Phd, Department of Physical Education University of Tehran, Kish International campus, Kish, Iran
Abstract
Background: Myocardial infarction is the irreversible cell death of a part of cardiac muscle as a result of a cut in blood flow. Atrial and ventricular natriuretic peptides (ANP & BNP) are strong indicators of myocardial infarction.This study aimed to evaluate the effect of six weeks intensive periodic training on the NT-pro BNP, BNP and ANP in rats after myocardial infarction.
Methods: Twelve Wistar male rats of 10 weeks old and mean weight 250-300gr were allocated in two groups with six rats in each group of experimental (60 minutes interval running on a treadmill, each cycle including four minutes of running with an intensity of 80-95% VO2max and two minutes of active recovery with a 45-50% VO2max intensity, three days a week for six weeks) and control group (without any precedent of training). Real-time PCR was used to assess the expression of NT-pro BNP, BNP and ANP genes after inducing MI (by blocking left coronary artery by surgery). Data were analyzed using independent t-test and SPSS 18 (α≤0.05).
Findings: The findings showed that there was significant decrease in the NT-pro BNP (p=0.001) and asignificant decrease in BNP and ANP respectively (P=0.067 and P≤0.475) after six weeks of intensive periodic training group compared to the control group.
Conclusion: In general, adaptation to intensive periodictraining was able to control and moderate the secretion of NT-proBNP and reduce BNP and ANP hormone secretion.
Keywords
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