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The Effects of Satureja Khuzestanica on Lipid Profile, Liver Enzymes, and Oxidative Stress Markers in Male Hamsters with High Fat Diet

Document Type : Original Article

Authors

1 Ph.D, Infertility Research Center, Shiraz University of Medical Sciences, Shiraz,

2 Associate Professor, Biochemistry Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

3 M.Sc. in Clinical Biochemistry, Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran

4 M.Sc. in Clinical Biochemistry, Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

5 Assistant Professor, Department of Nutrition and Biochemistry, Gonabad University of Medical Sciences, Gonabad, Iran

Abstract

Introduction: Satureja Khuzestanica (S. Khuzestanica) is one of the native plants of Iran that grows in areas such as Khuzestan and Lorestan. The current study was designed to evaluate the effects of S. Khuzestanica on lipid profile, especially on decreasing serum cholesterol, liver enzymes, and lipid peroxidation in male hamsters with high fat diet.
Methods: 26 male hamsters were randomly divided into control, high fat diet (HFD), and high fat diet treated with S. Khuzestanica (HFD+S) groups. After 10 days of beginning the study, the two latter groups were fed with high fat diet for 30 days. During the last 10 days, the HFD+S group was treated with 100mg/kg/day S. Khuzestanica through the gavage.
Results: Data showed that administration of S. Khuzestanica for 10 days resulted in a significant reduction of total cholesterol, LDL cholesterol, liver enzymes, and malondialdehyde in the HFD+S group.
Conclusion: These results support the potential effects of the use of Satureia Khuzestanica in the prevention and treatment of cardiovascular diseases.

Keywords

References
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Sadra Medical Journal
Volume 9, Issue 2
April 2021
Pages 119-130
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