ORIGINAL_ARTICLE
Impact of Maternal Empowerment Program on Discharge on their Satisfaction and Weight Gain of their Infant in Educational Hospital of Emem Reza University of Medical Sciences in Kermanshah
Background: The most important key causes of parents’ stress regarding their infant’s admission to the ICU include change in their role as the prime caregiver, feeling of quilt as to the suvival of their infant and his/her health, and the self-doubt of their ability to take care of their infant. The aim of this study was to determine the effectiveness of empowering mothers for their infant’s discharge on their satisfaction and weight gain of their infant. Method: Pre- and post-test clinical trials were conducted and 60 premature infants and their mothers from Kermanshah Neonatal ICU were selected using convenient sampling method. Mothers in the control group received routine care. In the intervention or experimental group, in addition to the routine care, the desired intervention were offered, providing mothers information about washing hands, feeding, reinforcement baby sucking, taking medication, touching and massaging the baby, bathing methods, teaching infection perevention methods, warning signs, and neonates care). Data were collected using a questionnaire for maternal and neonatal demographic information, and Mothers Satisfaction Questionnaire with 13 questions which was distributed to mothers at the time of admission and before discharge. The weight of the newborn was also measured 15 days after the discharge. The data were analyzed using independent T-Test and paired T-Test. Result: The findings showed that the mean score of satisfaction of mothers in the control and intervention group before discharge was significantly higher than the beginning of the study (P<0.001). Furthermore, the satisfaction rate of mothers in the control group was significantly lower than that of mothers in the intervention group (P<0.001). Neonatal weight during discharge was not statistically significant in the intervention and control groups (P=0.943). However, the weight gain of newborns 15 days after discharge in the intervention group was statistically significantly higher than that in the control group (p=0.001). Conclusion: The results showed that the mother’s presence on the infant’s bedside was an active part in the care of the infant and the exchange of information with the mother, enhancement of mothers satisfaction and constant high-quality care at home will result in better infant growth and better weight gain.
https://smsj.sums.ac.ir/article_45402_d8ccec4fdd35863777f57df1d072f010.pdf
2019-04-01
111
122
10.30476/smsj.2019.81499.
Body weight
Infant
Intensive care unit
Parental satisfaction
Mothers
Shahla
Moradi
shahlamoradi10@gmail.com
1
Department of Pediatrics Nursing, Personnel of the Social Security Organization Krmanshah, Kermanshah, Iran
AUTHOR
Sahra
Zendehzaban
zendezaban68@gmail.com
2
Department of Pediatrics Nursing, Nursing and Midwifery Faculty, Kermanshah University of Medical Sciences and Personnel of the Social Security Organization, Kermanshah, Iran
AUTHOR
Sousan
Valizadeh
valizadehsousan13@gmail.com
3
Professor of Nursing, Iranian Center for Evidence-Based Practice, Nursing and Midwifery School, Tabriz University of Medical Sciences, Tabriz, Iran
LEAD_AUTHOR
Nejat
Maleki
nejatmaleki11@gmail.com
4
Department of Pediatrics Nursing, Nursing and Midwifery Faculty, Sanandaj University of Medical Sciences, Sanandaj, Iran
AUTHOR
Leili
Tapak
lilytapak66@gmail.com
5
Department of Biostatistics and Epidmiology, School of public Health, Hamedan University of Medical Sciences, Hamedan, Iran
AUTHOR
Akbarbegloo M, Valizadeh L, Asadollahi M. Mothers and nurses viewpoint about importance and perceived nursing supports for parents with hospitalized premature newborn in natal intensive care unit. Journal of Critical Care Nursing. 2009;2(2):71-4.
1
Altman M, Vanpée M, Cnattingius S, Norman M. Moderately preterm infants and determinants of length of hospital stay. Archives of Disease in Childhood-Fetal and Neonatal Edition. 2009;94(6): 414-F8.
2
Aliabadi. The Effectiveness of Participatory maternal inthe Care ofpremature newborns in Neonatal Intensive Care Unit on rehospitalization Journal of School of Nursing and Midwifery, Tehran University of Medical Sciences. 2011;17(2):71-7.
3
Boykova M, Kenner C. Transition from hospital to home for parents of preterm infants. The Journal of Perinatal & Neonatal Nursing. 2012;26(1):81-7.
4
Verklan MT, Walden M. Core curriculum for neonatal intensive care nursing: Elsevier Health Sciences; 2010.
5
Ji H, Abushomar H, Chen X, Qian C, Gerson D. All-causereadmission to acute care for cancer patients. Healthcare quarterly (Toronto, Ont). 2011;15(3):14-6.
6
American Academy of Pediatrics Cofan. Hospital discharge of the high-risk neonate. Pediatrics. 2008;122(5):1119-26.
7
Information CIFH. All-cause readmission to acute care and return to the emergency department; 2012.
8
Petroua S, Eddamaa O, Manghamc L. Revisión estructurada de bibliografía reciente sobre las consecuencias económicas del parto prematuro. Rev Hosp Mat Inf Ramón Sardá 2011; 30 (1): 15-26.
9
Salas R, Sanhueza L, Maggi L. Factores de riesgo y seguimiento clínico en prematuros menores de 1 000 gramos. Revista chilena de pediatría. 2006;77(6):577-88.
10
Bouet KM CN RV, García-Fragoso L. Loss of parental role as a cause of stress inthe neonatal intensive care unit. Boletin de la Asociacion Medica de Puerto Rico. 2012;104(1):8-11.
11
Rogers C KH, Wallendorf M, Inder T. Identifying mothers of very preterm infants at-risk for postpartum depression and anxiety before discharge. Journal of Perinatology. 2012;33(3):171-6.
12
Tooten A HH HR, Winkel FW, Eliëns M,, Vingerhoets AJ vBH. The effectiveness of video interaction guidance in parents of premature infants: A multicenter randomised controlled trial. BMC pediatrics. 2012 12(1):76.
13
De Rouck S, Leys M. Information needs of parents of children admitted to a neonatal intensive care unit: A review of the literature (1990-2008). Patient education and counseling. 2009;76(2):159-73.
14
Lindberg B OK. Experiences of having a prematurelyborn infant from the perspective of mothers in northern Sweden. International journal of circumpolar health. 2008;67(5):461-71.
15
Franck LS OK, Nderitu S, Lim M, Fang S,, A. K. Parent involvement in pain management for NICU infants. Pediatr 2011;128(3):510-518.
16
Mamon J, Steinwachs DM, Fahey M, Bone LR, Oktay J, Klein L. Impact of hospital discharge planning on meeting patient needs after returning home Health Services Research Journal 1992;27(2):66-75.
17
Khajeh M, Karimi R, Sadat Hosseini AS. The effect of parents empowerment program on their belifs about parental role, behaviours and characteristics of their premature infants in NICU. Journal of Urmia Nursing And Midwifery Faculty. 2013;11(6):419-27.
18
Jones TL, Prinz RJ. Potential roles of parental self-efficacy in parent and child adjustment: A review. Clinical Psychology Review. 2005;25(3):341-63.
19
ORIGINAL_ARTICLE
Spiritual Well-being in Caregivers of Stroke Patients and its Effective Factors
Introduction: The stroke patients’ problems can lead to caregiver’s challenges. Therefore, it is important to identify caregiver’s spiritual well-being as a moderating factor in adapting to these challenges. The aim of this study was to determine the spiritual well-being of caregivers of stroke patients and to identify the factors affecting it. Methods: This was a cross-sectional study. One hundred and twenty two stroke patient caregivers were selected through convenience sampling. The Palutzian & Ellison Spiritual Well-being scale was used. Data were analyzed by SPSS software using t-test, ANOVA and Linear Regression analysis. Results: The mean score of spiritual well-being was 85.29 (SD=13.89). The spiritual well-being of caregivers was in moderate level, and the results showed the link between caregivers’ spiritual well-being and the patients’ age and education level. Caregivers’ spiritual well-being was associated with the patients’ ability to do personal activities and the way patient walked. In the case of those patients who were not able to do their personal activities, and who could not walk at all, their caregivers had higher mean score of spiritual well-being. The results of Linear Regression analysis showed an association between spiritual well-being and the patient’s walking ability (b=0.27, t=3.22, p=0.002) and their education level (b=-0.22, t=-2.59, p=0.01). Conclusion: The findings showed that the caregivers’ spiritual well-being was in moderate level. In addition, levels of education, age, the patient walking ability, and the ability to do personal activities were the factors associated with caregiver’s spiritual well-being. The patient's inability to walk and to perform personal activities were the factors that were associated to the caregiver spiritual well-being. Therefore, caregivers should try to increase their spiritual well-being when their patients are unable to move and have paralysis.
https://smsj.sums.ac.ir/article_45403_a5b3acd57caf503f08f24b9d206ad905.pdf
2019-04-01
123
132
10.30476/smsj.2019.81505.
Stroke
Spiritual well-being
Spiritual
Simin
Soudagar
sm.soudagar@yahoo.com
1
MS., Hormozgan University of Medical Sciences, Bandar Abbas, Iran
LEAD_AUTHOR
Merino JG. Clinical stroke challenges: A practical approach. AAN Enterprises; 2014.
1
Lui SK, Nguyen MH. Elderly stroke rehabilitation: overcoming the complications and its associated challenges. Current Gerontology and Geriatrics Research. 2018; 9. https://doi.org/10.1155/2018/9853837.
2
Vos T, Allen C, Arora M, Barber RM, Bhutta ZA, Brown A, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study. The Lancet. 2016;388(10053):1545-602.
3
Hatem SM, Saussez G, della Faille M, Prist V, Zhang X, Dispa D, et al. Rehabilitation of motor function after stroke: a multiple systematic review focused on techniques to stimulate upper extremity recovery. Frontiers in Human Neuroscience. 2016;10:442.
4
Divani AA, Vazquez G, Barrett AM, Asadollahi M, Luft AR. Risk factors associated with injury attributable to falling among elderly population with history of stroke. Stroke. 2009;40(10):3286-92.
5
Planton M, Peiffer S, Albucher J, Barbeau E, Tardy J, Pastor J, et al. Neuropsychological outcome after a first symptomatic ischaemic stroke with ‘good recovery’. European Journal of Neurology. 2012;19(2):212-9.
6
Pendlebury ST, Rothwell PM. Prevalence, incidence, and factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis. The Lancet Neurology. 2009;8(11):1006-18.
7
Mehdi Z, Birns J, Bhalla A. Post‐stroke urinary incontinence. International Journal of Clinical Practice. 2013;67(11):1128-37.
8
Chen Y-d, Li S-j, Sun F-h, Liu Y-y, Hu W-l. Monitoring of medical complications after acute ischemic stroke in a neurological intensive care unit. European Neurology. 2011;66(4):204-9.
9
Vermeij FH, op Reimer WJS, De Man P, Van Oostenbrugge RJ, Franke CL, De Jong G, et al. Stroke-associated infection is an independent risk factor for poor outcome after acute ischemic stroke: data from the Netherlands Stroke Survey. Cerebrovascular Diseases. 2009;27(5):465-71.
10
Rambod M, Soudagar S. Prevalence of Depression, Anxiety, and Stress among Caregivers’ of Patients with Stroke. Sadra Medical Sciences Journal. 2018;6(3):205-214.
11
Soleimani MA, Sharif SP, Allen KA, Yaghoobzadeh A, Nia HS, Gorgulu O. Psychometric properties of the persian version of spiritual well-being scale in patients with acute myocardial infarction. Journal of Religion and Health. 2017;56(6):1981-97.
12
Sadrollahi A. Spiritual Well-being and associated factors among the elderly population in Kashan. Iranian Journal of Geriatric Nursing. 2015;1(2):94-104.
13
Chafjiri RT, Navabi N, Shamsalinia A, Ghaffari F. The relationship between the spiritual attitude of the family caregivers of older patients with stroke and their burden. Clinical Interventions in Aging. 2017;12: 453.
14
Allahbakhshian M, Jaffarpour M, Parvizy S, Haghani H. A Survey on relationship between spiritual wellbeing and quality of life in multiple sclerosis patients. Zahedan Journal of Research in Medical Sciences. 2010;12(3):29-33.
15
Yazdi MH, Estaji Z, Heydari A. Study of the quality of life of nurses in Sabzevar hospitals in 2005-2006. Journal of Sabzevar University of Medical Sciences 2009; 16(1):50-56.
16
Abbasi M, Ghadampour E, Amirian L. The Impact of Spiritual Well-being on Psychological Distress in Patients with Spinal Cord Injury: The Mediating Role of Loneliness and Hopelessness. Journal of Research on Religion & Health 2018; 4(4):80-93.
17
Pierce LL, Steiner V, Havens H, Tormoehlen K. Spirituality expressed by caregivers of stroke survivors. West J Nurs Res. 2008;30(5):606-19.
18
Vespa A, Spatuzzi R, Merico F, Ottaviani M, Fabbietti P, Meloni C, et al. Spiritual well-being associated with personality traits and quality of life in family caregivers of cancer patients. Support Care Cancer. 2018;26(8):2633-40.
19
Spurlock WR. Spiritual well-being and caregiver burden in Alzheimer's caregivers. Geriatr Nurs. 2005;26(3):154-61.
20
Yoon KH, Moon YS, Lee Y, Choi SH, Moon SY, Seo SW, et al. The moderating effect of religiosity on caregiving burden and depressive symptoms in caregivers of patients with dementia. Aging Ment Health. 2018;22(1):141-7.
21
Newberry AG, Choi CW, Donovan HS, Schulz R, Bender C, Given B, et al. Exploring spirituality in family caregivers of patients with primary malignant brain tumors across the disease trajectory. Oncol Nurs Forum. 2013;40(3): 119-25.
22
Anum J, Dasti R. Caregiver Burden, Spirituality, and Psychological Well-Being of Parents Having Children with Thalassemia. J Relig Health. 2016;55(3):941-55.
23
Seyed Fatemi N, Rezaei M, Givari A, Hosseini F. Prayer and spiritual well-being in cancer patients. Payesh 2006; 5(4):295-303.
24
Clay KS, Talley C, Young KB. Exploring spiritual well‐being among survivors of colorectal and lung cancer. Journal of Religion & Spirituality in Social Work: Social Thought. 2010;29(1):14-32.
25
Yaghoobzadeh A, Soleimani MA, Allen KA, Chan YH, Herth KA. Relationship Between Spiritual Well-Being and Hope in Patients with Cardiovascular Disease. J Relig Health. 2018;57(3):938-50.
26
Zarei B, Vagharseyyedin SA, Gorganie E. Relationship Between Spiritual Well-Being and Self-Management Among Iranian People With Multiple Sclerosis. Jundishapur Journal of Chronic Disease Care. 2015;4(4): 30154.
27
Jeter BR. Spirituality and Psychological Well-Being Among ALS Caregivers: Hope and Perceived Stress as Mediators. 2016. Electronic Theses and Dissertations. Paper 3058. http://dc.etsu.edu/etd/3058.
28
ORIGINAL_ARTICLE
Barriers to the Hand Washing from the Viewpoint of Nurses: A Cross-sectional Study
Background: Hand washing is one of the most efficient and effective ways to prevent the transmission of microorganisms from one person or one place to the patients. However, despite the importance of hand washing by the medical personnel, the results of some studies indicate lack of proper hand washing by them. The present study aimed to determine the barriers to hand washing from the viewpoint of nurses working in general hospitals affiliated to Shiraz University of Medical Sciences in 2017. Materials and Methods: This was a cross-sectional and descriptive-analytical study conducted on 312 nurses working in general hospitals affiliated to Shiraz University of Medical Sciences. The required data were collected using a valid and reliable questionnaire consisting of two parts, including the studied nurses' demographic characteristics and 48 items related to the hand hygiene barriers in four dimensions of individual barriers (12 items), managerial barriers (19 items), equipment barriers (10 items), and environmental barriers (7 items). The collected data were analyzed using SPSS 21.0 through independent t-test and ANOVA. The p value of less than 0.05 was regarded as statistically significant. Results: The results showed that equipment barriers and individual barriers had, respectively, the highest (2.85 ± 0.65) and lowest (2.62 ± 0.46) means. Also, there were significant relationships between the means of managerial and equipment barriers and the studied nurses' sex, between the means of individual and managerial barriers and the nurses' employment status, between the means of equipment barriers and the nurses’ marital status, and finally, between the means of managerial barriers and the nurses' working shifts (P-value<0.05). Conclusion: According to the results, in order to remove the barriers to the nurses' hand washing, the following suggestions can be made: running adequate and appropriate training courses and developing a proper culture in the hospital wards to increase hand washing, using appropriate monitoring and motivational systems; providing timely, adequate facilities and equipment and also selecting appropriate disinfectants for nurses' hand washing, etc.
https://smsj.sums.ac.ir/article_45404_3922d5f5a2a129998ad87998b7c75157.pdf
2019-04-01
133
144
10.30476/smsj.2019.79246.
Nurses
Hand hygiene
Barriers
Nosocomial infections
Marziyeh
Geraei
marzieh.g72@gmail.com
1
Student Research Committee, MSc of Healthcare Management, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Mahboubeh
Sadeghi
mahboobe.sadeghi@gmail.com
2
BSc in Health Services Management, Student Research Committee, School of Management and Medical Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Ramin
Ravangard
ra_ranangard@yahoo.com
3
Health Human Resources Research Center, School of Management and Medical Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
1. Huis A, Hulscher M, Adang E, Grol R, van Achterberg T, Schoonhoven L. Cost-effectiveness of a team and leaders-directed strategy to improve nurses’ adherence to hand hygiene guidelines: a cluster randomised trial. International Journal of Nursing Studies. 2013;50(4):518-26.
1
2. Longtin Y, Sax H, Allegranzi B, Schneider F, Pittet D. Hand hygiene. New England Journal of Medicine. 2011;364:e24-e7.
2
3. Baloochi Beydokhti T, Gharcheh M, Bahri N, Basirimoghadam K. The Comparison of Hand Hygiene Compliance of alcohol-based solution and soap in Nurses of gonabad Hospitals-2009. The Horizon of Medical Sciences. 2010;16(3):64-70. (Persian)
3
4. Bagheri Nejad S, Allegranzi B, Syed S, Ellis B, Pittet D. Health-care-associated infection in Africa: a systematic review. Bulletin of the World Health Organization. 2011;89(10):757-65.
4
5. Allegranzi B, Bagheri Nejad S, Combescure C, Graafmans W, Attar H, Donaldson L, et al. Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis. Lancet. 2011;377(9761):228-41.
5
6. Parmeggiani C, Abbate R, Marinelli P, Angelillo IF. Healthcare workers and health care-associated infections: knowledge, attitudes, and behavior in emergency departments in Italy. BMC Infectious Diseases. 2010;10:35-43.
6
7. Sharma V, Dutta S, Taneja N, Narang A. Comparing hand-hygiene measures in a neonatal ICU: A randomized cross- over trial. Indian Pediatrics. 2013;50(10):917–21.
7
8. Kim S-K, Park H-Y, Lim Y-J, Kwak S-H, Hong M-J, Mun H-M, et al. Assessment of the Appropriateness of Hand Surface Coverage for Healthcare-Workers According to the WHO Hand Hygiene Guidelines. American Journal of Infection Control. 2013;41(6):S12-S3.
8
9. Lebovich G, Siddiqui N, Muller M. Predictors of hand hygiene compliance in the era of alochol-based hand rinse. Journal of Hospital Infection. 2013;83(4):276-83.
9
10. Scheithauer S, Eitner F, Mankartz J, Haefner H, Nowicki K, Floege J, et al. Improving hand hygiene compliance rates in the haemodialysis setting: more than just more hand rubs. Nephrology Dialysis Transplantation. 2012;27(2):766-70.
10
11. Erasmus V, Daha TJ, Brug H, Richardus JH, Behrendt MD, Vos MC, et al. Systematic review of studies on compliance with hand hygiene guidelines in hospital care. Infection Control and Hospital Epidemiology. 2010;31(3):283-94.
11
12. Widmer A, Rotter M, Voss A, Nthumba P, Allegranzi B, Boyce J, et al. Surgical hand preparation: state-of-the-art. Journal of Hospital Infection. 2010;74(2):112-22.
12
13. Najafi Gezelje T, Abbas Nejhad Z, Rafii F. A literature review of hand hygiene in Iran. Iran Journal of Nursing. 2013;25(80):1-13. (Persian)
13
14. Braswell ML, Spruce L. Implementing AORN recommended practices for surgical attire. Association of periOperative Registered Nurses journal. 2012;95(1):122-40.
14
15. Mamishi S, Pourakbari B, Teymuri M, Babamahmoodi A, Mahmoudi S. Management of hospital infection control in Iran: a need for implementation of multidisciplinary approach. Osong Public Health and Research Perspectives. 2014;5(4):179-86.
15
16. Abd Elaziz K, Bakr I. Assessment of knowledge, attitude and practice of hand washing among health care workers in Ain Shams University hospitals in Cairo Journal of Preventive Medicine and Hygiene. 2009;50(1):19-25.
16
17. Larson E. APIC guideline for handwashing and hand antisepsis in health care settings. American Journal of Infection Control. 1995;23(4):251-69.
17
18. Daneshmandi M, Samadipour E, Salari M. Hand hygiene practice in Sabzevar hospitals Iran. Journal of Sabzevar University of Medical Sciences. 2008;15(1):59-64. (Persian)
18
19. Arshadi bostan abad M, Assadollali M, Jebreili M, Mahallei M, Abdolalipour M. Nurses' attitudes towards barriers in hand hygiene in the neonatal units of Tabriz. Journal of Pediatric Nursing. 2014;1(1):18-26.
19
20. Scheithauer S, Eitner F, Mankartz J, Haefner H, Nowicki K, Floege J, et al. Improving hand hygiene compliance rates in the haemodialysis setting: more than just more hand rubs. Nephrology Dialysis Transplantation. 2011;27(2):766-70.
20
21. Weaver SJ RM, Salas E, Baum KD, King HB. Integrating the science of team training: guidelines for continuing education. Journal of Continuing Education in the Health Professions. 2010;30(4):208-20.
21
22. Brown J, Beaser R, Neighbours J, Shuman J. The integrated Joslin performance improvement/CME program: a new paradigm for better diabetes care. Journal of Continuing Education in the Health Professions. 2011;31(1):57-63.
22
23. Devnani M, Kumar R, Sharma RK, Gupta AK. A survey of hand-washing facilities in the outpatient department of a tertiary care teaching hospital in India. Journal of Infection in Developing Countries. 2010;5(2):114-8.
23
24. Kramer A HN, Below H, Heidecke C-D, Assadian O. Improving adherence to surgical hand preparation. Journal of Hospital Infection. 2008;70(1):35-43.
24
25. van Beeck E, Daha T, Richardus J, Vos M. A qualitative exploration of reasons for poor hand hygiene among hospital workers: lack of positive role models and of convincing evidence that hand hygiene prevents cross‐infection. Infection Control and Hospital Epidemiology. 2009;30(5):415-9.
25
26. Jang J, Wu S, Kirzner D, Moore C, Youssef G, Tong A, et al. Focus group study of hand hygiene practice among healthcare workers in a teaching hospital in Toronto, Canada. Infection Control and Hospital Epidemiology. 2010;31(2):144-50.
26
27. Sahebzadeh M, Hosseini SM, Javadi Nejad N, Farazandeh Mehr A. The study of equipment, safety, hygine, personnel standards and their correlation with employee performance in surgery department of the educational hospitals in Isfahan2009-2010. Hospital. 2011;10(2):1-12. (Persian)
27
28. Mertz D, Johnstone J, Krueger P, Brazil K, Walter S, Loeb M. Adherence to hand hygiene and risk factors for poor adherence in 13 Ontario acute care hospitals. American Journal of Infection Control. 2011;39(8):693-6.1.
28
ORIGINAL_ARTICLE
Effectiveness of Eight-week Acupuncture and Aquatic Exercise on the Amount of Pain, Motor Range and Quality of Life in Patients with lumbar Discopathy
Background: Since lumbar discopathy is a common disease and various traditional and ttherapeutic exercise methods are effective in treating it, the purpose of this study was a comparison of the effectiveness of eight-week acupuncture and aquatic exercise on the amount of pain, motor range and quality of life in patients with lumbar discopathy. Methods: The statistical sample in this study is comprised of 24 women who suffered from lumbar discopathy in Isfahan; they were divided into 2 groups of 12 people. After a specialist selected the subjects, the average score of pain, physical examination, physical evaluation of patients with low back pain and patient's quality of life were recorded by VAS, SLR test and quality of life questionnaire (SF36), respectively. The experimental group received a three-session aquatic exercise and acupuncture for 45-60 minutes for eight consecutive weeks. Then, to analyze the data, Kolmogorov-Smirnov test, T-test and independent t-test were used. Result: The results of this study showed that after eight weeks of acupuncture and aquatic exercise there was a significant effect on female patients’ pain, motor range and quality of life (P=0/00). However, there was no significant difference between the two groups in acupuncture and aquatic exercise (P=0/12) Conclusion: Acupuncture and aquatic exercise have a positive effect on reducing the amount of pain and improving the range of motion and quality of life in patients with lumbar discopathy. Therefore, individuals and patients suffering from lumbar pain should be advised to place acupuncture and exercise programs on the water in their daily programs to improve their pain, range of motion and quality of life.
https://smsj.sums.ac.ir/article_45405_8e14b1a4d234ab418db16b867608d11a.pdf
2019-04-01
145
160
10.30476/smsj.2019.79265.
Lower back pain
Acupuncture
Pain rate
Quality of life
Afrooz
Mostaghel
1
MSC sport injury and corrective exercise, Islamic Azad University of Khorasgan Branch, Isfahan, Iran
AUTHOR
Mohammad
Salaki
2
Associate professor of Physical medicine, Department of Sport Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Naser
Rahimi
na.rahimi2020@gmail.com
3
Associate professor of exercise physiology, Department of Physical Education and Sport Sciences, Imam Hossein university, Amir-Almomenin University, Isfahan, Iran
LEAD_AUTHOR
Campbell C, Muncer SJ. The Causes of Low Back Pain: a Network Analysis. Social Science & Medicine.2005; 60 (2):409- 419.
1
Maul I, Laubli T, Klipstein A, Kraeger H. Course of Low Back Pain Among Nurses: a Longitudinal Study Across Eight Years. Occupational and Environmental Medicine London Journal.2003; 60 (7): 497-503.
2
Tsauo JY, Chen WH, Liang HW, Jang Y. The Effectiveness of a Functional Training Programme for Patients with Chronic Low Back Pain - a Pilot Study. Disability and Rehabilitation.2009; 31(13):1100-1106.
3
Jhawar BS, Fuchs CS, Colditz GA, Stampfer MJ. Cardiovascular risk factors for physician-diagnosed lumbar disc herniation. Spine J; 2006; 6(6):684-91
4
Ghasemi GA, Rahimi N, Eshaghian M, Aghayari M. The Prevalence of Low Back Pain and its Correlation with Some Occupational Factors and Demographic Characteristics of the Nurses Working in the Hospitals Affiliated with Social Security Organization in Isfahan, 2011. Journal of Research Development in Nursing & Midwifery. 2014; 11(2) 69-76
5
Mcllveen B, Robertson JV. Randomized Controlled Study of the Outcome of Hydrotherapy for Subjects with Low Back or Back and Leg Pain. Physiotherapy. 1998; 84(1): 17-26.
6
Barker LK, Dawes H, Hansford P, Shamley D. Perceived and Measured Levels of Exertion of Patients With Chronic Back Pain Exercising in a Hydrotherapy Pool. Arch Phys Med Rehabil.2003; 84: 1319-1323.
7
Hayden JA, van Tulder MW, Malmivaara AV, Koes BW. Meta-analysis: exercise therapy for nonspecific low back pain. Ann Intern Med.2005, 142(9): 765-75.
8
Vickers AJ, Rusch VW, Malhotra VT, et al. Acupuncture is a feasible treatment for postthoracotomy pain: prospective pilot trial. BMC Anesthesiol 2006; 6: 5.
9
An J, Purepong N, Hunter RF, Kerr DP, Park J, Bradbury I, et al. Different frequencies of acupuncture treatment for chronic low back pain: An assessor-blinded pilot randomized controlled trial. Complement Ther Med. 2009; 17(3):131-40.
10
Yang JH. The effects of hand acupuncture therapy on pain, ROM, ADL and depression among elders with low back pain and knee joint pain. J Korean Acad Nurs. 2009; 39(1):10-20.
11
Giles LG, Muller R. Chronic spinal pain syndromes: A clinical pilot trial comparing acupuncture, a nonsteroidal anti-inflammatory drug and spinal manipulation. J Manipulative Physiol Ther. 1999; 22(6):376-81.
12
Ernst E. Acupuncture ineffective, attention effective? Arch Int Med. 2008; 168(5):551-2.
13
Han JS.physiology and neurochemical basis of acupuncture analgesia. In: Cheng To (ed) the international textbook of cardiology.pergamon, New York, 2003; 1124-1132.
14
Bensoussan A. Acupuncture meridians. Part 1.comp Thormed 2; 1994; 80-85.
15
Smith MO. An acupuncture program for the treatment of addicted personsl. Bull Narc 72. 2002; 35-41.
16
Liao SJ. Recent advances in the understanding of acupuncture. Yale J Biol Med51. 1978; 55-56.
17
Churojana O,Chawlparit A, chiewvit P, Charnchaowowanish P. The limited protocol MRI in diagnosis of lumbar disc herniation. Introduction. J med Assoc Thai 2006; 89(2):182-189.
18
Terry canle S, Jamesh B. Operative orthopaedics. 11th ed. China: Mosby; 2008.1871-1873.
19
Rebain R, Baxter GD, McDonough S. A systematic review of the straight ieg raising as a diagnostic aid for low back pain. Spine (Phila Pa 1976) 2002; 27(17):388-395.
20
Bites A. Hanson N. editors. Motion therapy in water. Mahdavi Nejad R. (Translators). Isfahan: Jahade Daneshgahi Isfahan, 2010 (Persian).
21
Keshner EA. Postural abnormalities in vestibular disorders. In: Herdman SJ, Editors. Vestibular Rehabilitation. Philadelphia: FA Davis Co: 1994; p. 47-67.
22
Bahrpeyma F. Comparison between the Effect of Medical Training Therapy and Stability Exercises on Functional Lumbar Instability. J Rafsanjan Univ Med Sci 2006; 5(1): 31-6.
23
Moseley L. Combined physiotherapy and education is efficacious for chronic low back pain. Aust J Physiother 2002; 48(4):297-302.
24
Lotfi, h.r. Atri, O. Hashemi, Javaheri, AS. Nowruz, K. Comparison of two therapeutic motion protocols on the inability and severity of pain in middle-aged men with chronic low back pain. Journal of Anesthesiology and Pain 2015; 6(1): 73-64.
25
Sedaghati n. Hemmatfar A. Behpoor N. Effect of central spinal stabilization muscle strengthening program on water level on pain intensity and lumbar lordosis. Bi-monthly Journal of Feyz 2013; 17(3): 274-267 (Persian).
26
Olson DA, Kolber MJ, Patel C, Pabian P, Hanney WJ. Aquatic Exercise for Treatment of Low-Back Pain A Systematic Review of Randomized Controlled Trials. American Journal of Lifestyle Medicine. 2013; 7(2):154-60.
27
Bello AI, Kalu NH, Adegoke BO, Agyepong-Badu S. Hydrotherapy versus land-based exercises in the management of chronic low back pain: a comparative study. Journal of Musculoskeletal Research. 2010; 13(04):159-65.
28
Dundar U, Solak O, Yigit I, Evcik D, Kavuncu V. Clinical effectiveness of aquatic exercise to treat chronic low back pain: a randomized controlled trial. Spine. 2009; 34(14):1436-40.
29
Oláh M, Molnár L, Dobai J, Oláh C, Fehér J, Bender T. The effects of weight bath traction hydrotherapy as a component of complex physical therapy in disorders of the cervical and lumbar spine: a controlled pilot study with follow-up. Rheumatology international.2008; 28(8):749-56.
30
Rezvani, M. Definition of acupuncture from the perspective of the West. Journal of Anesthesiology and Pain, 2011; 1(4): 12-1 (Persian).
31
Kargarfard M, Mehdi Dehghadani M, Reza Ghias R. The Effect of Aquatic Exercise Therapy on Muscle Strength and Joint's Range of Motion in Hemophilia Patients. Int J Prev Med. 2013; 4(1): 50–56
32
Joon-Shik Sh, In-Hyuk Ha, Jinho Le, Youngkwon Ch, Me-riong K, Byoung-Yoon p, Byung-Cheul Sh, Myeong Soo L. Effects of motion style acupuncture treatment in acute low back pain patients with severe disability: A multicenter, randomized, controlled, comparative effectiveness trial. 2013; 154:1030–1037.
33
Bonomi A, Patric D, Bushnell D. Validation of the united states’ version of the World Health Organization Quality of Life (WHOQOL) instrument. Journal of Clinical Epidemiology 2000; 53: 1-12.
34
Zargarzadeh, M. Memarian, R. Rafiee, A. The Effect of Progressive Muscle Relaxation Program on Chronic Lumbar Pain and Daily Living Activities of Patients with Interrupted Disks: a Clinical Trial. Journal of Shahrekord University of Medical Sciences.2014; 16 (6):101-110
35
Cuesta-Vargas AI, Adams N, Salazar J, Belles A, Hazañas S. Arroyo-Morales M. Deep water running and general practice in primary care for non-specific low back pain versus general practice alone: randomized controlled trial. Clinical rheumatology.2012; 31(7):1073-8. 70.
36
Lee JH, Ooi Y, Nakamura K. Measurment of muscle strengh of the trunck & the lower exterimities in subjects within history of low back pain.Spine 1995; 20(18): 1994-6.
37
Pedretti LW, Occuptional therapy Practice skill for physical dysfunction. 3rd ed. Battimore: Mosby; 1990. p. 532, 552 .
38
Braggins, back care 1th ed. Edinburg: Churchill Livingstone; 2000, P:265.
39
Arioshi M, Sonoda K, Nagata K, Mashima T, Zenmyo M, Paku CH, et al. Efficacy of aquatic exercises for patients with low back pain.Kurume Med J 1999; 46(2): 91-6.
40
ORIGINAL_ARTICLE
Study of the Duration and Causes of Prolonged Stay of Patients after Doctor's Discharge Order in Shahid Faghihi Hospital
Introduction: Due to the increasing difficulties and resource constraints in the field of health, the optimal use of health care facilities has received great attention. Therefore, using appropriate methods of management to avoid wasting limited hospital resources is of high significance. One of the key tools used as a lever to control and reduce health costs is to shorten the patient's length of stay. Accordingly, investigating the possible causes of prolongation of patients’ stay in the hospital and the proper use of hospital beds are among the most important issues with regard to the use of hospital facilities. Methods: The present study is an analytical-descriptive study, using a cross-sectional method to determine possible causes of prolongation of patients’ stay in the hospital after the issue of discharge order by physicians in Shahid Faghihi Hospital in 2016. The collected data were submitted to SPSS software and analyzed using t-test, Pearson correlation, and chi-square test. Results: The percentages of the patients who had extended their stay because of financial problems, unwillingness to leave the hospital, absence of insurance staff, lack of companions, lack of health insurance, and transference to other hospitals were 68.4%, 0.7%, 6.2%, 7.1%, 4.4%, and 11.1%, respectively. Conclusion: Hospital authorities’ awareness of the average prolongation of patients’ stay in the hospital and the reasons behind that can be effective in decision-making and planning for organizations. Recognizing such problems and proposing solutions to reduce patients’ length of stay and making plans for it can reduce unnecessary and excessive stays and hospitalizations; hence, reducing hospital costs.
https://smsj.sums.ac.ir/article_45406_32595ad0fa41a76b200429b734658231.pdf
2019-04-01
161
172
10.30476/smsj.2019.79247.
Length of stay
Patient discharge
hospital
Fatemeh
Sadeghipour
sadeqipor@gmail.com
1
BSc of Healthcare Management, Faculty of Management and Medical Information, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Marziyeh
Geraei
marzieh.g72@gmail.com
2
Student Research Committee, MSc of Healthcare Management, Mazandaran University of Medical Sciences, Sari, Iran
LEAD_AUTHOR
Zahra
Kavosi
zhr.kavosi@gmail.com
3
Health and Human Resource Management Research Center, Faculty of Management and Medical Information, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Ehsan
Abedini
abediniea961360@gmail.com
4
Student Research Committee, Health Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Ameri H, Adham D, Panahi M, Khalili Z, Fasihi A, Moravveji M et al . Predictors for Duration of Stay in Hospitals. j.health. 2015; 6 (3) :256-265. [Persian].
1
Hachesu PR, Ahmadi M, Alizadeh S, Sadoughi F. Use of Data Mining Techniques to Determine and Predict Length of Stay of Cardiac Patients.Healthcare Inform Res 2013; 19(2):121–9.
2
Cwynar R, Albert NM, Butler R, Hall C. Factors Associated With Long Hospital Length of Stay in Patients Receiving Warfarin After Cardiac Surgery. J Cardiovasc Nurs 2009; 24(6): 465-74.
3
Hachesu PR, Ahmadi M, Alizadeh S, Sadoughi F. Use of Data Mining Techniques to Determine and Predict Length of Stay of Cardiac Patients. Healthcare Inform Res 2013; 19(2):121–9.
4
Cannoodt LJ, Knickman JR. The effect of hospitall characteristics and organizational factors on pre- and postoperative lengths of hospital stay. Health Service Research 1984; 19 (5): 561-85.
5
Pourreza A , Salavati S, Sadeghi Darvishi S , Salehi Nasab, Tabesh H, Mamivand F, Kishi Zadeh Z. Factors Affecting the Duration of Hospitalization in Infectious Diseases of Razi Hospital in Ahvaz. Health Information Management 1393; 11 (6): 779-788.
6
Ravangard R, Arab M., RashidianA, Akbari Sari A, Niroumand N, et al. Evaluation of the duration of stay of patients admitted to the specialized educational hospital of Tehran University of Medical Sciences and the clinical and non-clinical factors affecting it. School of Public Health and Institute of Public Health Research 2010; 8 (3): 35-25.
7
Mansouri Arani M, Alaei Karhroodi F, Manouchehri H, Akbarzadeh Baghban A R. Audit of neonatal discharge process in neonatal intensive care unit at Mahdieh Medical Center, Tehran. Journal of Pediatric Nursing. 1394; 2 (2): 28-38.
8
Ajami S, Ketabi S. The study of bottlenecks in the discharge process of Isfahan Shahid Beheshti Hospital. Health Information Management 2008; 5 (1): 3-4.
9
Haghgoshaei A, Narimani MR, Modirshahla A KH, Takbiri A, Abolghasem Gorji H. Daily hospitals are a model for reducing the length of stay in hospitals. Health Management. 2011; 14 (46): 21-30. [Persian]
10
Yaghoubifar MA, Maskani K, Akabari A, Shahabipour F. The number of admissions and unnecessary residence days in patients in Sabzevar hospitals. Journal of Sabzevar University of Medical Sciences and Health Services. 2011: 3 (18). 224-232. [Persian]
11
Kawano T, Nishiyama K, Anan H, Tujimura Y. Direct relationship between aging and overcrowding in the ED, and a calculation formula for demand projection: a cross-sectional study. Emerg Med J 2014; 31(1): 19-23.
12
Karim H, Tara SM, Etminani K. Factors Associated with length of stay based on admission data in Qa'im and Imam Reza hospitals of Mashhad. Health Information Management. 2015; 12 (4): 405-415. [Persian]
13
Ameri H, Adham D, Panahi Tosanlu M, Khalili Z. Predictions for patient stay in hospital. Health and Hygiene. 1394: 6 (3). 256-265.
14
Karim H, Etminani K, Tara SM, Mardani M. Identify factors associated with length of hospital stay using decision tree. Health Informatics and Biomedical. 2015; 18 (61): 57-67. [Persian].
15
Hashemi-Fard A, Saffari SE, Adnan R. Analysis of hospitalization length for cerebrovascular accident patients in Sabzevar Vaseyee hospital using count regression models. Daneshvar University of Medical Sciences / Shahed University. 2013; 21(109): 1-7. [Persian]
16
Mirzaeyan S, Iezady A, Ebrazeh A, Mohammady P. Prediction of readmission based on LACE index in medical ward of Hajar hospital of Shahrekord. Journal of Clinical Nursing and Midwifery. 2014; 3 (2):1-12.
17
Lo SM, Choi KT, Wong EM, Lee LL, Yeung RS, Chan JT, et al. Effectiveness of Emergency Medicine Wards in reducing length of stay and overcrowding in emergency departments. Int Emerg Nurs 2014; 22(2): 116-20.
18
Karaca Z, Wong HS & Mutter RL. Duration of patients’ visits to the hospital emergency department. BMC Emergency Medicine 2012; 6(12): 15.
19
ORIGINAL_ARTICLE
Identification of Effective Factors on Facilitating Organizational Voice Based on Personnel Perspective of Governmental Hospitals of Mazandaran and Semnan Provinces Using Interpretive Structural Modeling
Introduction: In the present era, listening to the employee voice has become very important for organizations; therefore, the purpose of this study was to identify the effective factors on facilitating organizational voice based on personnel perspective of governmental hospitals of Mazandaran and Semnan provinces. Research Method: First, by examining theoretical foundations of research, main and subcomponents and effective indicators on organizational voice facilitation were identified and developed in the form of a score-board checklist. Based on the Delphi approach, efforts were made to confirm the indices and components of the research. Then, based on the interpretative structural modeling, effective factors on organizational voice facilitation were designed. Findings: Based on the research background, four factors and 16 criteria were identified. The positive beliefs of managers (X1), leadership style (X2), supervisor behavior (X3), atmosphere of trust and sense of suspicion (X4), accountability (X6), maintaining status que (X10) in the group of dependent variables, the components of non-conformity with the community (X5), demographic characteristics (X11), group thinking avoidance (X7) and trust and optimism to the administrator (X8) in the group of autonomic variables, organizational structure (X12), feedback mechanism (X13), job promotion and development (X14), organizational communications (X15), organizational culture (X16) and attitude and personality characteristics (X9) are in the group of independent variables. Conclusion: The results show that in the group of dependent variables, the factors affecting organizational voice have weak penetration power but somewhat have high dependence. In the group of independent variables, the factors affecting organizational voice have high penetration power but somewhat have low dependence.
https://smsj.sums.ac.ir/article_45407_29cc97efc73b14caef5fe7e1830a99b3.pdf
2019-04-01
173
184
10.30476/smsj.2019.81507.
Employee
Interpretative structural modeling
Hospitals
Akbar
Bahmani
bahmani.akbar@gmail.com
1
Assistant Professor of Public Administration, Payamenoor University, Tehran, Iran
LEAD_AUTHOR
Ali
Farhanian
alifarhanian@sums.ac.ir
2
Msc in Public Administration, Payamenoor University, Shiraz, Iran
AUTHOR
Van Dyne L, Cummings L L, McLean Parks J. Extra-role behaviors: In pursuit of construct and definitional clarity. In LL Cummings & BM Staw. Research in organizational behavior2012, 17: 215-285.
1
Crant MJ. Speaking up when encouraged: Predictingvoice behavior in a naturally-occurring setting. Paper presented at the annual meeting of the Academy of Management, Seattle; 2003.
2
Burris ER, Detert JR, Chiaburu DS. Quitting before leaving: The mediating effects of psychological attachment and detachment on voice. Journal of Applied Psychology 2008; 93(4): 912-922.
3
Morrison EW, Milliken FJ. Organizational silence: A barrier to change and development in a pluralistic world, Academy of Management Review 2015; 25: 706-725.
4
Liu W, Zhu RH, Yang YK. I warn you because I like you: Voice behavior, employee identifications, and transformational leadership. The Leadership Quarterly 2010; 21(1): 189–202.
5
Sabahat Bayrak K, Hatice Coban K. Organizational Voice Behaviour and its Investigation in Terms of Organizational Variables, European Journal of Scientific Research 2016; 12(35:16.
6
Abdul Latifand N Z, Mohd Arif L S. Employee Engagement and Employee Voice. International Journal of Academic Research in Progressive Education and Development 2018; 7(3): 507.
7
Darvish H, Shams M. Study of the Effect of political behavior on employee voice. Journal of State Administration Mission 2017; 8 (25):1-13 (Persian).
8
Bagherzadeh Khodashahri R, Hassanzadeh Pasikhani M S, Moazen Jamshidi MH. The Effect of Trust on Managers on Employee Voice: A Study on the Moderating Role of Empowering Behaviors of Managers. Journal of Management of Organizational Culture 2018; 16(2): 327.
9
Naghshbandi S S, Yousefi B, Zardoshtian S. The Impact of Social Capital and Perception of Organizational Political Behaviors on Organizational Voice and Silence of the Sports and Youth Organizations of Western Iran, PhD Thesis, Faculty of Physical Education of Razi University of Kermanshah; 2015 (Persian)
10
Shekari H, Hadadzadeh M, Bahremand M. The Effect of Ethical Leadership on Employee Voice due to the Mediating Role of Employees' Organizational Identity, Master's thesis of Payame Noor University of Yazd Province; 2017 (Persian).
11
Zhang Y. How to Promote Employee Voice Behavior: Analysis Based on Leadership Style Perspective. Journal of Research in Business, Economics and Management (JRBEM) 2018; 10(1):1814.
12
Prasadika G H H P, Nishanthi H M. Perceived employee voice and organizational commitment: A case of Sri Lanka. Asian Journal of Empirical Research 2018; 8(9): 330-341.
13
Wang Y, Zheng Y, Zhu Y. How transformational leadership influences employee voice behavior: The roles of psychological capital and organizational identification. Social behavior and Personality an International Journal 2018; 46(2): 313-322.
14
Takechi R, Chen Z, Chueung SY. Applying uncertainty management theory to employee voice behavior: an integrative investigation. Personnel Psychology 2012; 65: 283–323.
15
Nourian M. A Practical Guide to Analyzing the Content of Educational Media, Tehran, Amir Education Publishing; 2002 (Persian).
16
ORIGINAL_ARTICLE
Students’ Perception of Nursing Role Function (SP-NRF): Development and Psychometric Testing
Background: Although assessment of nursing students' perception of role function is very important, no questionnaire is currently available to measure this phenomenon. The aim of this study was to develop a students’ perception of nursing role function (SP-NRF) questionnaire and to test its psychometric properties. Methods: Developing the questionnaire and assessing its psychometric properties were performed through a cross-sectional study. The setting was School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran. Nursing students participated in this study. In the instrument development phase, 21 nursing students were asked to explain the secondary role function of nursing. The data were then analyzed by content analysis, giving 14 categories with 55 items. Afterwards, content validity rate (CVR) and content validity index (CVI) were determined. In the questionnaire's psychometric evaluation phase, 134 nursing students filled out the 52-item questionnaire. The construct validity was assessed, as well. Internal consistency and test-retest methods were used to assess the questionnaire's reliability. Results: The SP-NRF questionnaire consisted of 51 items across the following seven subscales: “professional ethical care activities", "holistic care activities", "educational and professional collaborative activities", "cultural and spiritual activities", "protective activities", "professional skills activities", and "supportive activities". The CVR and CVI in all the items were higher than 0.60 and 0.75, respectively. The final model in confirmatory factor analysis showed that this 51-item SP-NRF had a good fitness. Besides, Cronbach’s α for the total questionnaire and test-retest reliability were 0.967 and 0.793, respectively. Conclusion: The SP-NRF is a valid and reliable questionnaire for identifying the students’ perception of nursing role function. Measuring the nursing students' perception of role function not only enhances our understanding of this phenomenon, but it also helps design better curricula and teaching strategies for nursing students in order to prepare them to accept their roles in future.
https://smsj.sums.ac.ir/article_45408_5027263374c14c146d10b55bd418e46b.pdf
2019-04-01
185
200
10.30476/smsj.2019.81895.1011
Nursing role function
Nursing Student
Psychometric
Niloofar
Pasyar
npasyar@sums.ac.ir
1
PhD, Medical Surgical Nursing, Nursing and Midwifery School, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Mohammad
Khayyer
m_khayyer@yahoo.com
2
PhD, Prof of Educational Psychology, Shiraz University, Shiraz, Iran
AUTHOR
Bakan G, Akyol AD. Theory-guided interventions for adaptation to heart failure. Journal of advanced nursing. 2008;61(6):596-608.
1
Fawcett J. Contemporary nursing knowledge analysis and evaluation of nursing models and theories. Second ed. Philadelphia F.A. Davis Company 2005.
2
Roy C. Research based on the Roy adaptation model: last 25 years. Nursing science quarterly. 2011;24(4):312-20.
3
Dawson S. Pre-amputation assessment using Roy's Adaptation Model. British journal of nursing (Mark Allen Publishing). 1998;7(9):536-42.
4
Villareal E. Using Roy's adaptation model when caring for a group of young women contemplating quitting smoking. Public health nursing (Boston, Mass). 2003;20(5):377-84.
5
Posmontier B. Functional status outcomes in mothers with and without postpartum depression. Journal of midwifery & women's health. 2008;53(4):310-8.
6
Cook DA, Beckman TJ. Current concepts in validity and reliability for psychometric instruments: theory and application. The American journal of medicine. 2006;119(2):166 e7-16.
7
Vallerand AH. Development and testing of the inventory of functional status-chronic pain. Journal of pain and symptom management. 1998;15(2):125-33.
8
Tulman L, Fawcett J, Weiss M. The Inventory of Functional Status-Fathers. Development and psychometric testing. Journal of nurse-midwifery. 1993;38(5):276-82.
9
Tulman L, Fawcett J. Development of the Comprehensive Inventory of Functioning-Cancer. Cancer nursing. 2007;30(3):205-12.
10
Gholamzade S, Hazrati M. Roy adaptation model application in patient care. First ed. Tehran: Salemi; 2005.
11
Furåker C. Registered Nurses' views on their professional role. Journal of nursing management. 2008;16(8):933-41.
12
Hosseini M, Ashk Torab T, Taghdisi MH, Esmaeili Vardanjani SA. Study on situational influences perceived in nursing discipline on health promotion: a qualitative study. ISRN nursing. 2013;2013:218034.
13
Pasyar N, Sharif F, Rambod R. Nurses and Physicians’ Collaborative Behaviors in Intensive Care Units Sadra Med Sci J. 2017;5(4):239-250
14
Pasyar N, Rambod M, Gholamzadeh S, Sharif F. Correlation between Nurse /Manager Professional Collaborative Behaviors and Nurses’ Job Satisfaction. Iran Journal of Nursing. 2018;31(112):32-43.
15
Posmontier B. Functional status outcomes in mothers with and without postpartum depression. Journal of Midwifery & Women’s Health. 2008;53(4):310-8.
16
Kozier B. Fundamentals of nursing: concepts, process and practice: Pearson Education; 2008.
17
Manoochehri H, Imani E, Atashzadeh-Shoorideh F, Alavi-Majd A. Competence of novice nurses: role of clinical work during studying. Journal of medicine and life. 2015;8(Spec Iss 4):32.
18
Kemppainen V, Tossavainen K, Turunen H. Nurses' roles in health promotion practice: an integrative review. Health Promotion International. 2013;28(4):490-501.
19
Tulman L, Higgins K, Fawcett J, Nunno C, Vansickel C, Haas MB, et al. The inventory of functional status-antepartum period. Development and testing. Journal of nurse-midwifery. 1991;36(2):117-23.
20
McVeigh CA. Anxiety and functional status after childbirth. Australian College of Midwives Incorporated journal. 2000;13(1):14-8.
21
McVeigh C, Chaboyer W. Reliability and validity of the Inventory of Functional Status after Childbirth when used in an Australian population. Nursing & health sciences. 2002;4(3):107-12.
22
Newman DM. The Inventory of Functional Status-Caregiver of a Child in a Body Cast. Journal of pediatric nursing. 1997;12(3):142-7.
23
Ozkan S, Ogce F. Psychometric analysis of the Inventory of Functional Status--Cancer (IFS-CA) in Turkish women. Journal of transcultural nursing : official journal of the Transcultural Nursing Society / Transcultural Nursing Society. 2009;20(2):187-93.
24
Tulman L, Fawcett J, McEvoy MD. Development of the inventory of functional status-cancer. Cancer nursing. 1991;14(5):254-60.
25
Thomas-Hawkins C, Fawcett J, Tulman L. The Inventory of Functional Status-Dialysis: development and testing. ANNA journal / American Nephrology Nurses' Association. 1998;25(5):483-9.
26
Buckenham MA. Student nurse perception of the staff nurse role. Journal of advanced nursing. 1988;13(5):662-70.
27
Lawshe CH. A quantitative approach to content validity. Pers Psychol. 1975;28:563-75.
28
Waltz CF, Strickland OL, Lenz ER. Measurement in Nursing and Health Research. Fourth ed. New York: Springer Publishing Company; 2010.
29
Waltz CF, Strickland O, Lenz E. Measurement in nursing research. Philadelphia: FA Davis Company; 1991.
30
Yaghmaie F. Factors affecting the use of computerised information systems in community health. 1997.
31
Furaker C. Registered Nurses' views on their professional role. J Nurs Manag. 2008;16(8):933-41.
32
Polit DF, Beck CT, Owen SV. Is the CVI an acceptable indicator of content validity? Appraisal and recommendations. Research in nursing & health. 2007;30(4):459-67.
33
Waltz CF, Bausell RB. Nursing research: Design, statistics, and computer analysis. In: Waltz CF, editor. Philadelphia: FA Davis company; 1981. p. 304.1.
34
ORIGINAL_ARTICLE
Relationship between Temporomandibular Dysfunction and Joint Morphology
Background: Temporomandibular dysfunction (TMD) is one of the most prevalent jaw disorders, and it is considered as the main cause of orofacial pain of non-dental origin. TMD has different etiologies, which are not yet fully known. The morphology of the components of the temporomandibular joint (TMJ) has been discussed as an etiological factor of TMD. These parameters include the position of the condyle in the articular fossa, the horizontal angle of the condyle, and the slope, width and height of the articular eminence. The possible relationship between the TMJ morphology and the incidence of TMD has been reviewed in this study. Method: This paper is not a systematic review but is a review of literature on the relationship between TD and JM. A computerized search of five electronic databases, including PubMed, Medline, Scopus, Web of Sciences and google scholar from 1st January 1980 to June 2018 was conducted. “Temporomandibular dysfunction”, “Temporomandibular joint” and “morphology” were used as key phrases. Results: The search revealed 102 papers that were screened in detail. Owing to a lack of relevance to the subject area, 59 papers were excluded. Thus, the review consisted of 43 clinically relevant papers that met all the criteria. Conclusion: Most of the selected studies included in this review article revealed that that TMJ morphology plays an important role in the pathogenesis of TMD. Therefore, the morphologic variation of the joint should be considered as an important element in the pathogenesis of TMD.
https://smsj.sums.ac.ir/article_45409_94ec589cccd86d3277fcf3ddadeaecbd.pdf
2019-04-01
201
210
10.30476/smsj.2019.81900.1012
Temporomandibular joint
Morphology
Temporomandibular dysfunction
Maryam
Paknahad
paknahadmaryam@yahoo.com
1
Assistant professor, Department of Oral and maxillofacial Radiology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Kaur B, Sehgal R, Logani A, Dhar P. Morphometric evaluation of temporomandibualr joint using cone beam computed tomography (CBCT). Am J Oral Med Radiol. 2015;2(4):169-76.
1
White SC, Pharoah MJ. Oral radiology: principles and interpretation: Elsevier Health Sciences; 2014.
2
Barghan S, Tetradis S, Mallya S. Application of cone beam computed tomography for assessment of the temporomandibular joints. Aust Dent J 2012;57(s1):109-18.
3
Cortés D, Exss E, Marholz C, Millas R, Moncada G. Association between disk position and degenerative bone changes of the temporomandibular joints: an imaging study in subjects with TMD. Cranio. 2011;29(2):117-26.
4
Ozkan A, Altug HA, Sencimen M, Senel B. Evaluation of articular eminence morphology and inclination in TMJ internal derangement patients with MRI. Int J Morphol. 2012;30:740-4.
5
Bashizade H, Mofidi N. Correlation between eminence steepness and condyle disk movements in temporomandibular joints affected by internal derangements using magnetic resonance imaging. J Dent Med. 2013;25(4):579-84.
6
Hirata FH, Guimarães AS, Oliveira JXd, Moreira CR, Ferreira ETT, Cavalcanti MGP. Evaluation of TMJ articular eminence morphology and disc patterns in patients with disc displacement in MRI. Braz Oral Res. 2007;21(3):265-71.
7
Shahidi S, Vojdani M, Paknahad M. Correlation between articular eminence steepness measured with cone-beam computed tomography and clinical dysfunction index in patients with temporomandibular joint dysfunction. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116(1):91-7.
8
Sülün T, Cemgil T, Duc J-MP, Rammelsberg P, Jäger L, Gernet W. Morphology of the mandibular fossa and inclination of the articular eminence in patients with internal derangement and in symptom-free volunteers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92(1):98-107.
9
Sümbüllü M, Çağlayan F, Akgül H, Yilmaz A. Radiological examination of the articular eminence morphology using cone beam CT. Dentomaxillofac Radiol. 2012;41(3):234.
10
Pullinger AG, Seligman DA. Multifactorial analysis of differences in temporomandibular joint hard tissue anatomic relationships between disk displacement with and without reduction in women. J Prosthet Dent. 2001;86(4):407-19.
11
Paknahad M, Shahidi S. Association between mandibular condylar position and clinical dysfunction index. J Cranio Maxillofac Surg. 2015;43(4):432-6.
12
Katsavrias EG. Changes in articular eminence inclination during the craniofacial growth period. Angle Orthod 2002;72(3):258-64.
13
Kranjčić J, Vojvodić D, Žabarović D, Vodanović M, Komar D, Mehulić K. Differences in articular-eminence inclination between medieval and contemporary human populations. Arch Oral Biol. 2012;57(8):1147-52.
14
Žabarović D, Jerolimov V, Carek V, Vojvodić D, Žabarović K, Buković Jr D. The effect of tooth loss on the TM-joint articular eminence inclination. Coll Antropol. 2000;24(1):37-42.
15
Isberg A, Westesson P-L. Steepness of articular eminence and movement of the condyle and disk in asymptomatic temporomandibular joints. Oral Surg Oral Med Oral Pathol Oral Radiol. 1998;86(2):152-7.
16
Okeson JP. Management of temporomandibular disorders and occlusion: Elsevier Health Sciences; 2014.
17
Parker MW. A dynamic model of etiology in temporomandibular disorders. J Am Dent Assoc. 1990;120(3):283-90.
18
Atkinson WB, Bates Jr RE. The effects of the angle of the articular eminence on anterior disk displacement. J Prosthet Dent. 1983;49(4):554-5.
19
Sharma S, Gupta D, Pal U, Jurel SK. Etiological factors of temporomandibular joint disorders. National J Maxillofacial surg. 2011;2(2):116.
20
Hall M, Gibbs C, Sclar A. Association between the prominence of the articular eminence and displaced TMJ disks. Cranio. 1984;3(3):237-9.
21
Kerstens HC, Tuinzing DB, Golding RP, Van der Kwast WA. Inclination of the temporomandibular joint eminence and anterior disc displacement. International journal of oral and maxillofacial surgery. 1989;18(4):228-32.
22
Paknahad M, Shahidi S, Akhlaghian M, Abolvardi M. Is Mandibular Fossa Morphology and Articular Eminence Inclination Associated with Temporomandibular Dysfunction? Journal of Dentistry, Shiraz University of Medical Sciences. 2016;17(2):134-41.
23
Sato H, Fujii T, Kitamori H. The clinical significance of the horizontal condylar angle in patients with temporomandibular disorders. Cranio. 1997;15(3):229-35.
24
Sato S, Kawamura H, Motegi K, Takahashi K. Morphology of the mandibular fossa and the articular eminence in temporomandibular joints with anterior disk displacement. International journal of oral and maxillofacial surgery. 1996;25(3):236-8.
25
Keller D, Carano A. Eminence-posterior occlusal plane angle in patients with temporomandibular disorders. Cranio. 1991;9(2):159-64.
26
Ren Y-F, Isberg A, Westesson P-L. Steepness of the articular eminence in the temporomandibular joint: tomographic comparison between asymptomatic volunteers with normal disk position and patients with disk displacement. Oral Surg Oral Med Oral Pathol Oral Radiol. 1995;80(3):258-66.
27
Alkhader M, Al-Shawaf R. Cone-beam computed tomography findings of temporomandibular joints with osseous abnormalities. Oral Radiol. 2012;28(2):82-6.
28
Tsuruyama K, Nishimura H, Motoda E, Maeda T. Morphological changes of the articular eminence and the anterior disc displacement in youngsters. Pediatr Dent J. 2006;16(2):145-53.
29
Kurita H, Ohtsuka A, Kobayashi H, Kurashina K. Is the morphology of the articular eminence of the temporomandibular joint a predisposing factor for disc displacement? Dentomaxillofac Radiol. 2000;29(3):159-62.
30
Almăşan OC, Hedeşiu M, Băciuţ G, Leucuţa DC, Băciuţ M. Disk and joint morphology variations on coronal and sagittal MRI in temporomandibular joint disorders. Clin Oral Investig. 2013;17(4):1243-50.
31
Gateno J, Anderson PB, Xia JJ, Horng JC, Teichgraeber JF, Liebschner MA. A comparative assessment of mandibular condylar position in patients with anterior disc displacement of the temporomandibular joint. J Oral Maxillofac Surg. 2004;62(1):39-43.
32
Ikeda K, Kawamura A. Disc displacement and changes in condylar position. Dentomaxillofac Radiol. 2014;42(3).
33
Incesu L, Taşkaya-Yılmaz N, Öğütcen-Toller M, Uzun E. Relationship of condylar position to disc position and morphology. Eur J Radiol. 2004;51(3):269-73.
34
Kurita H, Ohtsuka A, Kobayashi H, Kurashina K. A study of the relationship between the position of the condylar head and displacement of the temporomandibular joint disk. Dentomaxillofac Radiol. 2001;30(3):162-5.
35
Mazzetto MO, Veneziam GC, Magri LV, Nasr MK, Paiva AF, Paiva G. Evaluation of the condylar position in subjects with signs and symptoms of functional disorders of the temporomandibular joint through images made with cone beam computed tomography on the sagittal plane. Braz Dent Sci. 2014;17(2):77-82.
36
Peroz I, Doz P, Seidel A, Griethe M, Lemke A-J. MRI of the TMJ: morphometric comparison of asymptomatic volunteers and symptomatic patients. Quintessence Int. 2011;42(8).
37
Rammelsberg P, Jäger L, Duc J-MP. Magnetic resonance imaging-based joint space measurements in temporomandibular joints with disk displacements and in controls. Oral Surg Oral Med Oral Pathol Oral Radiol. 2000;90(2):240-8.
38
Vasconcelos Filho JO, de Menezes AV, de Freitas DQ, Manzi FR, Bóscolo FN, de Almeida SM. Condylar and disk position and signs and symptoms of temporomandibular disorders in stress-free subjects. J Am Dent Assoc. 2007;138(9):1251-5.
39
Cho B-H, Jung Y-H. Osteoarthritic changes and condylar positioning of the temporomandibular joint in Korean children and adolescents. Imaging Sci Dent. 2012;42(3):169-74.
40
Scapino RP. Histopathology associated with malposition of the human temporomandibular joint disc. Oral Surg Oral Med Oral Pathol Oral Radiol. 1983;55(4):382-97.
41
Tsuruta A, Yamada K, Hanada K, Hosogai A, Kohno S, Koyama J-i, et al. The relationship between morphological changes of the condyle and condylar position in the glenoid fossa. Journal of orofacial pain. 2004;18(2):148-56.
42
de Senna BR, Marques LS, França JP, Ramos-Jorge ML, Pereira LJ. Condyle-disk-fossa position and relationship to clinical signs and symptoms of temporomandibular disorders in women. Oral Surg Oral Med Oral Pathol Oral Radiol. 2009;108(3):e117-e24.
43
Okur A, Ozkiris M, Kapusuz Z, Karaçavus S, Saydam L. Characteristics of articular fossa and condyle in patients with temporomandibular joint complaint. Eur Rev Med Pharmacol Sci. 2012;16(15):2131-5.
44
Paknahad M, Shahidi S, Iranpour S, Mirhadi S, Paknahad M. Cone-Beam Computed Tomographic Assessment of Mandibular Condylar Position in Patients with Temporomandibular Joint Dysfunction and in Healthy Subjects. International journal of dentistry. 2015;2015.
45
Pereira L, Gaviao M, Bonjardim L, Castelo P. Ultrasound and tomographic evaluation of temporomandibular joints in adolescents with and without signs and symptoms of temporomandibular disorders: a pilot study. Dentomaxillofac Radiol. 2014.
46
Major PW, Kinniburgh RD, Nebbe B, Prasad NG, Glover KE. Tomographic assessment of temporomandibular joint osseous articular surface contour and spatial relationships associated with disc displacement and disc length. Am J Orthod Dentofacial Orthop. 2002;121(2):152-61.
47
Peng-cheng H, Duan-qiang Z. Condylar position and condylar symmetry in patients with temporomandibular disorders. Shanghai Kou Qiang Yi Xue. 2012;21(6).
48
Savakkanavar MB, Sridhar S, Dinesh D, Girish K, Ramesh G. Association of temporomandibular joint dysfunction, condylar position and dental malocclusions in Davangere population. J Contemp Dent Pract. 2012;13(4):528-33.
49
Westesson P-L, Bifano JA, Tallents RH, Hatala MP. Increased horizontal angle of the mandibular condyle in abnormal temporomandibular joints: A magnetic resonance imaging study. Oral Surg Oral Med Oral Pathol Oral Radiol. 1991;72(3):359-63.
50
Westesson P, Liedberg J, Manstein CH. Horizontal condylar angle in relation to internal derangement of the temporomandibular joint. Plastic Reconstructive Surg. 1988;82(5):927.
51
Sanromán JF, Gonzalez JG, Del Hoyo JA. Relationship between condylar position, dentofacial deformity and temporomandibular joint dysfunction: an MRI and CT prospective study. J Cranio Maxillofac Surg. 1998;26(1):35-42.
52
Hüls A, Walter E, Schulte W, Freesmeyer W. Computertomographische Stadieneinteilung des dysfunktionellen Gelenkkopfumbaus. Dtsch Zahnärztl. 1985(40):37-51.
53
Vieira-Queiroz I, Torres MG, de Oliveira-Santos C, Campos PF, Crusoé-Rebello I. Biometric parameters of the temporomandibular joint and association with disc displacement and pain: a magnetic resonance imaging study. International journal of oral and maxillofacial surgery. 2013;42(6):765-70.
54
Hasegawa H, Saitoh I, Nakakura-Ohshima K, Shigeta K, Yoshihara T, Suenaga S, et al. Condylar shape in relation to anterior disk displacement in juvenile females. Cranio. 2011;29(2):100-10.
55
de Farias J, Melo S, Bento P, Oliveira L, Campos P, de Melo D. Correlation between temporomandibular joint morphology and disc displacement by MRI. Dentomaxillofac Radiol. 2015;44(7):20150023.
56
ORIGINAL_ARTICLE
Pancreatic Cancer: From Genome to New Therapies
Pancreatic cancer is ranked as the fourth leading cause of cancer related death. The survival rate of patients is very low and the mortality rate in men is higher than that of women. Various hereditary and non- hereditary factors are involved in the formation of pancreatic cancer; one of the important non- hereditary factors is smoking. Besides, it is known that the risk of pancreatic cancer in patients with diabetes mellitus is twice as high as in the non-diabetic population. Hereditary conditions also include genetic (activation of oncogenes and inactivation of tumor suppressor genes) and epigenetic changes (lncRNA). The mutation in KRAS oncogene is observed in 95% of the patients with pancreatic cancer. Despite the common use of ultrasound and tumor markers in diagnosing pancreatic cancer, their importance as powerful diagnostic tools has been challenged. An innovation in common therapeutic strategies such as chemotherapy, immunotherapy, and gene therapy based on genetic vectors has provided a promising tool for treatment. Using oncolytic viruses with selective proliferation in cancer cells and minimal adverse effects has opened a new perspective on the future of treatment of this cancer. In addition, novel technologies in gene editing including CRISPR have allowed the genome manipulation of cancer cells to identify and regulate the molecular pathways involved in pancreatic cancer. Considering that multiple genetic and epigenetic changes play a role in the pathogenesis of this cancer, simultaneous control of these pathways with multiple therapies can be a useful therapeutic strategy for pancreatic cancer.
https://smsj.sums.ac.ir/article_45410_978ab6f12d46e488b25befbc0cca7375.pdf
2019-04-01
211
224
10.30476/smsj.2019.79287.
Pancreatic cancer
Genetics
Oncolytic Viruses
CRISPR
Mahsa
Moshari
m.moshari1397@gmail.com
1
Student of B.Sc., Department of Biological Science, Faculty of Basic Science, Higher Education Institute of Rab-Rashid, Tabriz, Iran
AUTHOR
Asiyeh
Jebelli
asiyehjebelli@yahoo.com
2
Assistant Professor, Department of Biological Science, Faculty of Basic Science, Higher Education Institute of Rab-Rashid, Tabriz, Iran
LEAD_AUTHOR
Kanji ZS, Gallinger S. Diagnosis and management of pancreatic cancer. CMAJ. 2013;185(14):1219-26.
1
Salem AA, Mackenzie GG. Pancreatic cancer: A critical review of dietary risk. Nutrition Research. 2018;52:1-13.
2
Del Chiaro M, Segersvärd R, Lohr M, Verbeke C. Early detection and prevention of pancreatic cancer: is it really possible today? World J Gastroenterol 2014;20(34):12118-30.
3
Pourshams A, Kazemi B, Kalantari S. A review of the etiology and biomarkers of pancreatic cancer, with emphasis on the role of diabetes: review article. Tehran Univ Med J. 2018;75(11):773-8.
4
Fazeli Z, Fazeli Bavandpour F, Abdi A, Pour Hosaingholi M, Bastaminezhad. Trend analysis of Pancreatic Cancer Mortality in Iran. JIUMS. 2013;20(4):239-45.
5
Pourhoseingholi MA, Fazeli Z, Ashtari S, Bavand-Pour FSF. Mortality trends of gastrointestinal cancers in Iranian population. Gastroenterol Hepatol Bed Bench. 2013;6(Suppl 1):52-7.
6
Taefi A, Noraee M, Ghorbani A, Fakheri H, Zaheri MJ, Semnani A, et al. Investigation of the incidence of pancreatic and bile ducts cancers in Iran: a population-based study. Govaresh. 2008;13(4):217-22.
7
Thomas C. Risk factors, biomarker and imaging techniques used for pancreatic cancer screening. Chin Clin Oncol. 2017;6(6):1-10.
8
Kleeff J, Korc M, Apte M, La Vecchia C, Johnson CD, Biankin AV, et al. Pancreatic cancer. Nat Rev Dis Primers. 2016;2:16022-35.
9
Kikuyama M, Kamisawa T, Kuruma S, Chiba K, Kawaguchi S, Terada S, et al. Early Diagnosis to Improve the Poor Prognosis of Pancreatic Cancer. Cancers. 2018;10(2):48-54.
10
Freelove R, Walling A. Pancreatic Cancer: Diagnosis and Management. Am Fam Physician. 2006;73(3):485-92.
11
Cicenas J, Kvederaviciute K, Meskinyte I, Meskinyte-Kausiliene E, Skeberdyte A, Cicenas J. KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 mutations in pancreatic cancer. Cancers. 2017;9(5):42-7.
12
Khan MA, Azim S, Zubair H, Bhardwaj A, Patel GK, Khushman M, et al. Molecular drivers of pancreatic cancer pathogenesis: looking inward to move forward. Int J Mol Sci. 2017;18(4):779-86.
13
Eser S, Schnieke A, Schneider G, Saur D. Oncogenic KRAS signalling in pancreatic cancer. Br J Cancer. 2014;111:817-22.
14
Muzumdar MD, Chen P-Y, Dorans KJ, Chung KM, Bhutkar A, Hong E, et al. Survival of pancreatic cancer cells lacking KRAS function. Nat Commun. 2017;8(1):1090-101.
15
Srivastava SK, Bhardwaj A, Arora S, Singh S, Azim S, Tyagi N, et al. MYB is a novel regulator of pancreatic tumour growth and metastasis. Br J Cancer. 2015;113(12):1694-703.
16
Tyagi N, Marimuthu S, Bhardwaj A, Deshmukh SK, Srivastava SK, Singh AP, et al. p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling. Cancer lett. 2016;370(2):260-7.
17
Boeck S, Jung A, Laubender RP, Neumann J, Egg R, Goritschan C, et al. EGFR pathway biomarkers in erlotinib-treated patients with advanced pancreatic cancer: translational results from the randomised, crossover phase 3 trial AIO-PK0104. Br J Cancer. 2013;108(2):469-76.
18
Asghar U, Witkiewicz AK, Turner NC, Knudsen ES. The history and future of targeting cyclin-dependent kinases in cancer therapy. Nat Rev Drug Discov. 2015;14(2):130-46.
19
Naderi E, Mostafaei M, Pourshams A, Mohamadkhani A. Network of microRNAs-mRNAs interactions in pancreatic cancer. Biomed Res Int. 2014;2014:1-8.
20
Moschovis D, Gazouli M, Tzouvala M, Vezakis A, Karamanolis G. Long non-coding RNA in pancreatic adenocarcinoma and pancreatic neuroendocrine tumors. Annals of Gastroenterology. 2017;30(6):622-8.
21
Wang F, Herrington M, Larsson J, Permert J. The relationship between diabetes and pancreatic cancer. Mol cancer. 2003;2(1):4-9.
22
Mizuno S, Nakai Y, Isayama H, Yanai A, Takahara N, Miyabayashi K, et al. Risk factors and early signs of pancreatic cancer in diabetes: screening strategy based on diabetes onset age. Am J Gastroenterol. 2013;48(2):238-46.
23
Darmawan G, Simadibrata M. Pancreatic Cancer: Review of Etiology, Clinical Features, Diagnostic Procedures, Treatment and Mesothelin Role. Indo J Gastro Hepa Diges Endo. 2011;12(1):44-9.
24
Chang JC, Kundranda M. Novel diagnostic and predictive biomarkers in pancreatic adenocarcinoma. Int J Mol Sci. 2017;18(3):667-71.
25
Rouanet M, Lebrin M, Gross F, Bournet B, Cordelier P, Buscail L. Gene Therapy for Pancreatic Cancer: Specificity, Issues and Hopes. Int J Mol Sci. 2017;18(6):1231-40.
26
Yin H, Kanasty RL, Eltoukhy AA, Vegas AJ, Dorkin JR, Anderson DG. Non-viral vectors for gene-based therapy. Nat Rev Genet. 2014;15(8):541-55.
27
Midoux P, Pichon C, Yaouanc JJ, Jaffrès PA. Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers. Br J Pharmacol. 2009;157(1):166-78.
28
Bertrand E, Gonçalves C, Billiet L, Gomez JP, Pichon C, Cheradame H, et al. Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer. Chem comm. 2011;47(46):12547-9.
29
Kasuya H, Takeda S, Nomoto S, Nakao A. The potential of oncolytic virus therapy for pancreatic cancer. Cancer Gene Ther. 2005;12:725-36.
30
Nishimoto T, Yoshida K, Miura Y, Kobayashi A, Hara H, Ohnami S, et al. Oncolytic virus therapy for pancreatic cancer using the adenovirus library displaying random peptides on the fiber knob. Gene Ther. 2009;16:669-80.
31
Nakao A, Takeda S, Shimoyama S, Kasuya H, Kimata H, Teshigahara O, et al. Clinical experiment of mutant herpes simplex virus HF10 therapy for cancer. Curr Cancer Drug Targets. 2007;7(2):169-74.
32
Nakao A, Kasuya H, Sahin T, Nomura N, Kanzaki A, Misawa M, et al. A phase I dose-escalation clinical trial of intraoperative direct intratumoral injection of HF10 oncolytic virus in non-resectable patients with advanced pancreatic cancer. Cancer Gene Ther. 2011;18(3):167-75.
33
O’Leary MP, Choi AH, Kim S-I, Chaurasiya S, Lu J, Park AK, et al. Novel oncolytic chimeric orthopoxvirus causes regression of pancreatic cancer xenografts and exhibits abscopal effect at a single low dose. J Transl Med 2018;16(1):110-8.
34
Butler K. Reviews of Science for Science Librarians: CRISPR-Cas9 Revolutionizes Gene Editing. Sci & Tech Libraries. 2016;35(3):221-7.
35
Garneau JE, Dupuis M-È, Villion M, Romero DA, Barrangou R, Boyaval P, et al. The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature. 2010;468:67.
36
Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelson T, et al. Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells. Sci. 2013;343:84-7.
37
Kelley ML, Strezoska Ž, He K, Vermeulen A, Smith AvB. Versatility of chemically synthesized guide RNAs for CRISPR-Cas9 genome editing. Journal of Biotechnology. 2016;233:74-83.
38
Chiou S-H, Winters IP, Wang J, Naranjo S, Dudgeon C, Tamburini FB, et al. Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing. Genes Dev. 2015;29:1-10.
39
Maresch R, Mueller S, Veltkamp C, Öllinger R, Friedrich M, Heid I, et al. Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice. Nat Commun. 2016;7:10777-86.
40
Lehner F, Kulik U, Klempnauer J, Borlak J. The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases. The FASEB Journal. 2007;21(7):1445-62.
41
Li J, Zhang Y, Gao Y, Cui Y, Liu H, Li M, et al. Downregulation of HNF1 homeobox B is associated with drug resistance in ovarian cancer. Oncology reports. 2014;32(3):979-88.
42
Vorvis C, Hatziapostolou M, Mahurkar-Joshi S, Koutsioumpa M, Williams J, Donahue TR, et al. Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2016;310(11):G1124-G37.
43
Seino T, Kawasaki S, Shimokawa M, Tamagawa H, Toshimitsu K, Fujii M, et al. Human pancreatic tumor organoids reveal loss of stem cell niche factor dependence during disease progression. Cell stem cell. 2018;22(3):454-67.
44