نوع مقاله: مقاله مروری

نویسندگان

1 دکترای بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران

2 دانشجوی دکترا بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران

3 دانشجوی فوق لیسانس بیوشیمی بالینی، دانشکده پزشکی، دانشگاه علوم پزشکی شیراز، شیراز، ایران

چکیده

تداخل در عملکرد طبیعی شبکه آندوپلاسمی تحت شرایط استرس منجر به راه اندازی مسیر کاملاً حفاظت شده ای تحت نام پاسخ استرس سلولی  یا پاسخ پروتئینهای تا نخورده (UPR; Unfolded protein response) می گردد که هدف اولیه این مسیر جبران اختلالات ایجاد شده یا بازگرداندن شرایط نرمال سلولی است و درصورت طولانی و شدید بودن استرس شبکه آندوپلاسمی حتی قادر به راه اندازی مسیر مرگ سلولی (Apoptosis) نیز می باشد. مسیر پاسخ به استرس پروتئین های بد تا شده دارای سه بازوی اصلی است که هریک پس از فعال شدن منجر به اثرات متفاوتی بر تغییر بیان ژنهای ضروری درون سلول می شوند. در سالهای اخیر مولکولهای تنظیم کننده پاسخ استرس شبکه آندوپلاسمی بعنوان گزینه های  بسیار قوی و موثر برای اهداف دارویی و درمانی در بسیاری از بیماری ها از جمله : سرطان، آلزایمر، پارکینسون، دیابت، بیماری های قلبی و کبدی و آلرژی مورد توجه محققین قرار گرفته اند.

کلیدواژه‌ها

عنوان مقاله [English]

Evaluation of Endoplasmic Reticulum Stress Mechanism and Unfold Protein Response Signaling in Cancer

نویسندگان [English]

  • Pouneh Mokaram 1
  • Sanaz Dastghaib 2
  • Morvarid Siri 3
  • Sedigheh Rezayi 3

1 PhD of clinical biochemistry, Department of biochemistry, Shiraz University of medical sciences, Shiraz, Iran

2 PhD candidate in clinical biochemistry, Department of biochemistry, Shiraz University of medical sciences, Shiraz, Iran

3 Master of clinical biochemistry, Department of biochemistry, Shiraz University of medical sciences, Shiraz, Iran

چکیده [English]

Perturbation of endoplasmic reticulum (ER) homeostasis under a stressful situation leads to a stress condition termed “ER stress” which induces the activation of a finely regulated program defined as unfolded protein response (UPR), whose primary aim is to restore disorders or normal cell conditions. Under prolonged or sustained ER, stress conditions may result in activation-induced cell death. The UPR has three main arms; activation of each arm can lead to various effects on the expression of essential genes in cells.
In recent years, ER stress response regulator molecules have been considered by the researchers as a very strong and effective candidate for pharmaceutical and therapeutic purposes in many diseases, including cancer, Alzheimer's disease, Parkinson's disease, diabetes, heart and liver diseases, and allergies.

کلیدواژه‌ها [English]

  • Endoplasmic reticulum
  • Stress
  • cancer
  • UPR
  • Protein Folding
  • Cell death mechanisms

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